Semin Arthritis Rheu:室外空气污染与患类风湿性关节炎风险的关联

2020-03-22 xiangting MedSci原创

现有证据表明,空气污染的某些指标(臭氧、靠近公路和PM2.5)与RA之间存在显著关联。

空气污染是全球疾病负担的高风险因素之一。空气污染与类风湿性关节炎(RA)的关系仍存在争议。这项系统评价和荟萃分析探讨了室外空气污染与出现RA之间的关联。

研究人员检索了PubMed、Embase和Web of science(最后一次检索,2019年5月21日)。使用随机效应模型进行荟萃分析,并用相对风险(RRs)表示综合效应。

从1296篇文章中确定了8项研究。臭氧(O3)暴露与RA之间关联的汇总RR为1.16(95%CI:1.15,1.18)。与居住地离公路较远相比,对于住宅距离公路≤50m的人群,RA风险与靠近公路相关性的汇总RR为1.34(95%CI:1.11,1.62)。与之相反,PM2.5暴露与RA间存在反作用,对血清阳性RA进行亚组分析发现PM10有相似结果。另外,PM10、CO、NO2和NO2(10年前)暴露与RA风险之间没有明确证据。

现有证据表明,空气污染的某些指标(臭氧、靠近公路和PM2.5)与RA之间存在显著关联。为使证据具有可推广性,应将研究范围扩大到空气污染(包括室内)严重的发展中国家,以更全面地了解RA的危险因素。

原始出处:

Dongsheng Di. Long-term exposure to outdoor air pollution and the risk of development of rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis Rheu. April 2020.

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    2020-03-24 zhaojie88
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