PLoS One:颅内动脉狭窄的数量与卒中严重程度独立相关

2016-10-31 MedSci MedSci原创

目的:研究者旨在探讨颅内动脉狭窄数量(NSMIA),狭窄的程度及卒中危险因素与缺血性脑卒中的严重程度的相关性。方法:研究者对行全脑血管造影(DSA)确诊的缺血性脑卒中进行回顾性分析研究。采用美国国立卫生院卒中量表(NIHSS)评定卒中的严重程度。计数双侧颈内动脉和椎动脉狭窄的血管数目。结果: 从一个中心招募83例患者纳入研究。NSMIA与卒中的严重程度显著相关(皮尔森相关系数= 0.485,P<0

目的:研究者旨在探讨颅内动脉狭窄数量(NSMIA),狭窄的程度及卒中危险因素与缺血性脑卒中的严重程度的相关性。

方法:研究者对行全脑血管造影(DSA)确诊的缺血性脑卒中进行回顾性分析研究。采用美国国立卫生院卒中量表(NIHSS)评定卒中的严重程度。计数双侧颈内动脉和椎动脉狭窄的血管数目。

结果:从一个中心招募83例患者纳入研究。NSMIA与卒中的严重程度显著相关(皮尔森相关系数= 0.485,P<0.001),与与狭窄程度(皮尔森相关系数= 0.01,P = 0.90)不相关。多元回归分析显示,校正卒中危险因素后,NSMIA与NIHSS评分显著相关。校正后的比值比(每侧)为2.092(95%CI 为0.865至3.308,P = 0.001)。校正常见危险因素后,狭窄程度也明显与NIHSS评分显著相关。比值比(每10%)为0.712(95%CI,1.223为0.202,P = 0.007)。

结论:颅内大动脉狭窄的数量独立于狭窄程度和其他卒中危险因素,与缺血性脑卒中的严重程度相关。先前的研究没有患者DSA相关详细数据。研究强调了卒中患者检测所有主要动脉的重要性。

原始出处:

Wei X, Liu Z,et al. The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity. PLoS One. 2016 Sep 20.


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    2016-11-18 gospel007

    有创意的研究。

    0

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    2016-11-02 保守主义

    有意思!

    0

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