Adaptimmune和Noile-Immune宣布合作,开发增强型SPEAR T细胞肿瘤免疫疗法

2019-08-28 不详 MedSci原创

治疗癌症的T细胞疗法的领导者Adaptimmune Therapeutics和日本东京的创新型癌症免疫疗法Noile-Immune Biotech公司宣布,将共同开发下一代共同表达IL-7和CCL19的SPEAR T细胞产品,并结合Noile-Immune的PRIME(增殖诱导和迁移增强)技术。

治疗癌症的T细胞疗法的领导者Adaptimmune Therapeutics和日本东京的创新型癌症免疫疗法Noile-Immune Biotech公司宣布,将共同开发下一代共同表达IL-7和CCL19的SPEAR T细胞产品,并结合Noile-Immune的PRIME(增殖诱导和迁移增强)技术。

"我们最近开始了我们的肉瘤2期临床试验,称为SPEARHEAD-1以及SURPASS试验,这是我们的第一个下一代产品临床试验。我们将继续开发增强型产品,旨在提高抗肿瘤的疗效和耐久性回应",Adaptimmune管道研究高级副总裁Karen Miller说,"与Noile-Immune的合作使我们制备能够分泌IL-7和CCL19的下一代SPEAR T细胞,这不仅可以改善我们设计的SPEAR T细胞的增殖和运输,还可以改善患者自身的T-细胞。这种增强的T细胞增殖和运输可以增强癌症患者的抗肿瘤活性。"

Adaptimmune将拥有在全球范围内开发和商业化最终产品的专有权。Adaptimmune将在所有计划中向Noile-Immune支付高达3.12亿美元的现金支付和里程碑付款。

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    2019-11-25 智慧医人
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    2019-10-04 kalseyzl
  4. [GetPortalCommentsPageByObjectIdResponse(id=1779038, encodeId=db2b1e79038df, content=<a href='/topic/show?id=c1a41946d9' target=_blank style='color:#2F92EE;'>#Adaptimmune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1946, encryptionId=c1a41946d9, topicName=Adaptimmune)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jul 25 06:41:00 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921041, encodeId=246c19210419c, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Nov 25 20:41:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779027, encodeId=896f1e790270e, content=<a href='/topic/show?id=5e05194410' target=_blank style='color:#2F92EE;'>#ADAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1944, encryptionId=5e05194410, topicName=ADAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Fri Oct 04 11:41:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728118, encodeId=e96b1e2811834, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jul 10 08:41:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794256, encodeId=35421e9425646, content=<a href='/topic/show?id=78181659647' target=_blank style='color:#2F92EE;'>#SPEAR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16596, encryptionId=78181659647, topicName=SPEAR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f54230, createdName=xlysu, createdTime=Fri Jul 17 18:41:00 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264725, encodeId=056c1264e25fe, content=<a href='/topic/show?id=150f19229c' target=_blank style='color:#2F92EE;'>#ADA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1922, encryptionId=150f19229c, topicName=ADA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374352, encodeId=7f1513e435243, content=<a href='/topic/show?id=6d5d56912e' target=_blank style='color:#2F92EE;'>#DAPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5691, encryptionId=6d5d56912e, topicName=DAPT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519411, encodeId=b50f1519411c9, content=<a href='/topic/show?id=e0e49e6858' target=_blank style='color:#2F92EE;'>#immune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9768, encryptionId=e0e49e6858, topicName=immune)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521491, encodeId=b163152149198, content=<a href='/topic/show?id=0e108281e8f' target=_blank style='color:#2F92EE;'>#肿瘤免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82817, encryptionId=0e108281e8f, topicName=肿瘤免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=995711357332, createdName=drwjr, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=)]
    2020-07-10 feather89
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    2020-07-17 xlysu
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    2019-08-30 般若傻瓜
  7. [GetPortalCommentsPageByObjectIdResponse(id=1779038, encodeId=db2b1e79038df, content=<a href='/topic/show?id=c1a41946d9' target=_blank style='color:#2F92EE;'>#Adaptimmune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1946, encryptionId=c1a41946d9, topicName=Adaptimmune)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jul 25 06:41:00 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921041, encodeId=246c19210419c, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Nov 25 20:41:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779027, encodeId=896f1e790270e, content=<a href='/topic/show?id=5e05194410' target=_blank style='color:#2F92EE;'>#ADAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1944, encryptionId=5e05194410, topicName=ADAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Fri Oct 04 11:41:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728118, encodeId=e96b1e2811834, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jul 10 08:41:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794256, encodeId=35421e9425646, content=<a href='/topic/show?id=78181659647' target=_blank style='color:#2F92EE;'>#SPEAR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16596, encryptionId=78181659647, topicName=SPEAR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f54230, createdName=xlysu, createdTime=Fri Jul 17 18:41:00 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264725, encodeId=056c1264e25fe, content=<a href='/topic/show?id=150f19229c' target=_blank style='color:#2F92EE;'>#ADA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1922, encryptionId=150f19229c, topicName=ADA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374352, encodeId=7f1513e435243, content=<a href='/topic/show?id=6d5d56912e' target=_blank style='color:#2F92EE;'>#DAPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5691, encryptionId=6d5d56912e, topicName=DAPT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519411, encodeId=b50f1519411c9, content=<a href='/topic/show?id=e0e49e6858' target=_blank style='color:#2F92EE;'>#immune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9768, encryptionId=e0e49e6858, topicName=immune)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521491, encodeId=b163152149198, content=<a href='/topic/show?id=0e108281e8f' target=_blank style='color:#2F92EE;'>#肿瘤免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82817, encryptionId=0e108281e8f, topicName=肿瘤免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=995711357332, createdName=drwjr, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=)]
    2019-08-30 mnda
  8. [GetPortalCommentsPageByObjectIdResponse(id=1779038, encodeId=db2b1e79038df, content=<a href='/topic/show?id=c1a41946d9' target=_blank style='color:#2F92EE;'>#Adaptimmune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1946, encryptionId=c1a41946d9, topicName=Adaptimmune)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jul 25 06:41:00 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1921041, encodeId=246c19210419c, content=<a href='/topic/show?id=f9af13291a4' target=_blank style='color:#2F92EE;'>#Oil#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13291, encryptionId=f9af13291a4, topicName=Oil)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Nov 25 20:41:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779027, encodeId=896f1e790270e, content=<a href='/topic/show?id=5e05194410' target=_blank style='color:#2F92EE;'>#ADAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1944, encryptionId=5e05194410, topicName=ADAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Fri Oct 04 11:41:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728118, encodeId=e96b1e2811834, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jul 10 08:41:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794256, encodeId=35421e9425646, content=<a href='/topic/show?id=78181659647' target=_blank style='color:#2F92EE;'>#SPEAR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16596, encryptionId=78181659647, topicName=SPEAR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f54230, createdName=xlysu, createdTime=Fri Jul 17 18:41:00 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264725, encodeId=056c1264e25fe, content=<a href='/topic/show?id=150f19229c' target=_blank style='color:#2F92EE;'>#ADA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1922, encryptionId=150f19229c, topicName=ADA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374352, encodeId=7f1513e435243, content=<a href='/topic/show?id=6d5d56912e' target=_blank style='color:#2F92EE;'>#DAPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5691, encryptionId=6d5d56912e, topicName=DAPT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519411, encodeId=b50f1519411c9, content=<a href='/topic/show?id=e0e49e6858' target=_blank style='color:#2F92EE;'>#immune#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9768, encryptionId=e0e49e6858, topicName=immune)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521491, encodeId=b163152149198, content=<a href='/topic/show?id=0e108281e8f' target=_blank style='color:#2F92EE;'>#肿瘤免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82817, encryptionId=0e108281e8f, topicName=肿瘤免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=995711357332, createdName=drwjr, createdTime=Fri Aug 30 04:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=)]
    2019-08-30 quxin068
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