JACC:替格瑞洛联合阿司匹林对PCI术后的抗血栓影响

2020-02-22 不详 MedSci原创

本研究的目的旨在比较和评估替格瑞洛以及替格瑞洛联合乙酰水杨酸(ASA)对接受药物洗脱支架冠脉介入治疗患者的抗血栓形成效果。TWILIGHT临床试验将接受PCI治疗患者在3个月的双重抗血栓形成治疗中随机分成替格瑞洛+安慰剂治疗和替格瑞洛联合ASA治疗,主要终点事件是花生四烯酸刺激后的血栓大小。最终共纳入分析了51名患者,随访结束后的血栓面积在两组患者中无明显差异(p=0.22),在对环氧化酶-1阻断

本研究的目的旨在比较和评估替格瑞洛以及替格瑞洛联合乙酰水杨酸(ASA)对接受药物洗脱支架冠脉介入治疗患者的抗血栓形成效果。

TWILIGHT临床试验将接受PCI治疗患者在3个月的双重抗血栓形成治疗中随机分成替格瑞洛+安慰剂治疗和替格瑞洛联合ASA治疗,主要终点事件是花生四烯酸刺激后的血栓大小。最终共纳入分析了51名患者,随访结束后的血栓面积在两组患者中无明显差异(p=0.22),在对环氧化酶-1阻断敏感的标记物,包括对花生四烯酸和胶原的血小板反应性方面,安慰剂组的患者要更高,而血小板反应性水平与二磷酸腺苷和凝血酶无明显差异。

研究结果显示,对于接受药物洗脱冠脉支架植入的患者,替格瑞洛和替格瑞洛联合ASA治疗在抗血栓形成方面无明显差异,但对环氧化酶-1阻断敏感的标记物在联合ASA治疗组中更低。

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    2020-05-07 hbwxf
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    2020-11-10 zxl736
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    2020-02-24 gwc388

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