JCC: 炎症性肠病更容易得精神疾病以及自杀!

2021-04-12 MedSci原创 MedSci原创

炎症性肠病主要包括克罗恩病(UC)和溃疡性结肠炎(UC),这种极易复发的疾病通常需要药物和外科手术的综合治疗,同时会给患者带来极大的身心影响。

      炎症性肠病主要包括克罗恩病(UC)和溃疡性结肠炎(UC),这种极易复发的疾病通常需要药物和外科手术的综合治疗,同时会给患者带来极大的身心影响。目前已经有多项研究证实IBD与心理健康问题(如自杀)之间存在联系,最近有研究还发现,自杀未遂在儿童IBD患者中更为常见,这更加引起了社会对于IBD患者精神健康的关注。本项研究的目的是探究成年IBD患者中发生精神疾病和自杀的风险。

 

      研究人员通过基于全瑞典的人群的队列研究(1973-2013年),收集了69865名成年IBD患者中关于精神疾病和自杀风险的临床数据(溃疡性结肠炎:n = 43,557;克罗恩病:n = 21,245; IBD未定型:n = 5063),同时收集了这些患者的兄弟姐妹的临床数据,普通对照人群为3472913名。

 

 

      在11年的中位随访期间,研究人员发现IBD患者中有7465(10.7%)例首次出现精神疾病(发生率IR:8.4/1000人年),总人群中有306911(9.9%)例精神疾病的发生(IR 6.6),炎症性肠病患者比正常人群发生精神疾病的风险要高1.3倍(95%CI = 1.2-1.3)。在IBD诊断后的第一年(HR = 1.4,95%CI = 1.2-1.6)和有肠外表现的患者(HR = 1.6,95%CI = 1.5-1.7)的精神病发病率最高。同时在所有IBD类型中自杀未遂的风险增加(HRs = 1.2-1.4),而自杀既遂与CD(HR = 1.5)明确相关!

图:炎症性肠病导致精神疾病的危险因素

 

      本项研究发现成人IBD患者与精神疾病和自杀未遂的风险增加有关。对IBD患者,尤其是具有肠外表现和老年IBD患者,应进行心理随访,以减少自杀行为的出现。

 

 

原始出处:

Jonas F Ludvigsson. Et al. Association between inflammatory bowel disease and psychiatric morbidity and suicide: A Swedish nationwide population-based cohort study with sibling comparisons . Journal of Crohn's and Colitis.2021.

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    2021-09-02 来了个搞笑的

    自杀既遂与CD(HR = 1.5)明确相关!🤔🤔

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1013815, encodeId=5e021013815ae, content=自杀既遂与CD(HR = 1.5)明确相关!🤔🤔, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dcb5439452, createdName=来了个搞笑的, createdTime=Thu Sep 02 17:23:08 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547432, encodeId=420a154e4322b, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Apr 14 13:25:56 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956493, encodeId=10b4956493d7, content=👇👇👇【 扫码入群】 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/4e312a21700d44deb480cde139da3b22.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 10:47:12 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956470, encodeId=da2a9564e0ee, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手**:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Tue Apr 13 10:06:06 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1013815, encodeId=5e021013815ae, content=自杀既遂与CD(HR = 1.5)明确相关!🤔🤔, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dcb5439452, createdName=来了个搞笑的, createdTime=Thu Sep 02 17:23:08 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547432, encodeId=420a154e4322b, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Apr 14 13:25:56 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956493, encodeId=10b4956493d7, content=👇👇👇【 扫码入群】 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/4e312a21700d44deb480cde139da3b22.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 10:47:12 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956470, encodeId=da2a9564e0ee, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手**:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Tue Apr 13 10:06:06 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1013815, encodeId=5e021013815ae, content=自杀既遂与CD(HR = 1.5)明确相关!🤔🤔, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dcb5439452, createdName=来了个搞笑的, createdTime=Thu Sep 02 17:23:08 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547432, encodeId=420a154e4322b, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Apr 14 13:25:56 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956493, encodeId=10b4956493d7, content=👇👇👇【 扫码入群】 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=[AttachmentDto(url=https://img.medsci.cn/comment/20210413/4e312a21700d44deb480cde139da3b22.png, type=image, width=464, height=464)], authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 13 10:47:12 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956470, encodeId=da2a9564e0ee, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手**:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Tue Apr 13 10:06:06 CST 2021, time=2021-04-13, status=1, ipAttribution=)]
    2021-04-13 first smile

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手**:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

    0

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