Intens Care Med:入院前暴露于空气污染会延长重症监护患者的人工通气时间

2020-04-11 MedSci原创 MedSci原创

入住ICU之前,短期的环境空气污染暴露是ICU患者人工通气持续时间的危险因素。

暴露于空气污染物是导致肺部疾病发作或加剧的严重危险因素。然而,重症监护前环境空气污染物暴露对辅助呼吸时间长短的影响尚未明确。

近日,危重病医学领域权威杂志Intensive Care Medicine上发表了一篇研究文章,研究人员收集并分析了2003年入住安特卫普大学医院(比利时法兰德斯)重症监护病房(ICU)的患者的病历,这些患者在入住ICU时或入院后48小时内进行了人工通气,持续时间至少48小时。根据每个患者的家庭住址,研究人员使用高分辨率的时空模型来模拟入院前不超过10天的患者每日空气污染物暴露量[颗粒物空气动力学直径≤2.5 µm(PM2.5)和≤10 µm(PM10)、二氧化氮(NO2)和黑碳(BC)]。研究人员使用负二项式回归拟合的分布式滞后模型评估人工通气持续时间与入住ICU前10天内空气污染暴露之间的关联。

控制预先指定的混杂因素,入院前10天,BC的IQR升高(1.2 µg/m3)与估计的人工通气持续时间累积增加12.4%(95%CI为4.7-20.7)相关。研究人员还观察到PM2.5、PM10和NO2与人工通气时间累积增加估计值范围为7.8%至8.0%显著相关。

由此可见,入住ICU之前,短期的环境空气污染暴露是ICU患者人工通气持续时间的危险因素。

原始出处:

Annick Weerdt.et al.Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients.Intensive Care Medicine.2020.https://www.esicm.org/icm-search/?id=doi:10.1007/s00134-020-05999-3#article

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    2020-04-13 bioon6
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    2020-04-13 智慧医人
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    2020-04-11 qingfengqishi5

    学习了,学习了

    0

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