NEJM:精神疾病患者后续医疗事件风险研究

2020-04-30 MedSci原创 MedSci原创

大多数精神障碍患者后续医疗事件的风险增加,危险比从0.82到3.62不等,并根据精神障碍诊断后的时间而变化

精神障碍患者的后续医疗风险高于一般人群。
 
近日研究人员使用了丹麦人口队列数据,队列包括1900年至2015年在丹麦出生的590多万人口数据,总计随访8390万人-年。研究人员评估了10大类精神障碍和9大类医疗事件调整后,研究人员使用Cox回归模型计算精神障碍和后续医疗事件的风险关系。
 
在5940299参与者中,共有698874人(11.8%)患有精神障碍。研究开始时,总人口的中位年龄为32.1岁,最后一次随访时为48.7岁。总体上,精神障碍与后续医疗事件之间的危险比为1.37。器质性精神障碍与癌症的危险比最低为0.82,饮食障碍和泌尿生殖系统疾病的危险比最高为3.62,精神分裂症与肌肉骨骼疾病风险降低。在精神障碍被诊断后15年内出现疾病的绝对风险从发育障碍患者的泌尿生殖道疾病的0.6%到患有器质性精神障碍者循环障碍的54.1%不等。
 
研究证实,大多数精神障碍患者后续医疗事件的风险增加,危险比从0.82到3.62不等,并根据精神障碍诊断后的时间而变化。
 
原始出处:
 
Natalie C. Momen et al. Association between Mental Disorders and Subsequent Medical Conditions. N Engl J Med, April 30, 2020.

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