Stroke:抗磷脂抗体与缺血性卒中风险

2020-09-29 MedSci原创 MedSci原创

aPL并不是成人RIS的独立预测因子。但是,考虑到非标准化的疾病标准,应考虑进一步设计良好的前瞻性试验以证实这些结果。

尽管抗磷脂抗体(aPL)与血栓形成事件相关,尤其是在年轻患者中,但尚不清楚aPL在复发性缺血性卒中(RIS)中的作用。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项系统评价和荟萃分析旨在评估aPL与RIS之间的关联。

根据系统评价和荟萃分析的首选报告项目(PRISMA),研究人员通过计算机辅助检索了PubMed、EMBASE和Cochrane图书馆中1990年以来以英语或韩语发表的文献,并进行了系统评价。Review Manager 5.3软件用于统计分析。

在2272篇检索的文献中,研究人员纳入了8项研究(2510名受试者;844名aPL阳性受试者)。荟萃分析发现对于RIS,aPL的相对风险为1.41(95%CI为0.91-2.17;I2=54%)。在亚组分析中,年龄<50岁、民族和aPL类型并未增加RIS的发生风险。

由此可见,aPL并不是成人RIS的独立预测因子。但是,考虑到非标准化的疾病标准,应考虑进一步设计良好的前瞻性试验以证实这些结果。

原始出处:

Yerim Kim,et al.Antiphospholipid Antibody and Recurrent Ischemic Stroke A Systematic Review and Meta-Analysis.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030431

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200926/6acfc563dea348a49bf7592d1da41432/dbd5d140356a4140b7a0a2aee769926f.jpg, createdBy=39a95421810, createdName=ms3000001831800181, createdTime=Tue Sep 29 15:16:37 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026697, encodeId=f402102669e39, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045983, encodeId=ba4a10459834c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], 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    2020-11-17 1391f0aeeem

    好文章,学习了

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200926/6acfc563dea348a49bf7592d1da41432/dbd5d140356a4140b7a0a2aee769926f.jpg, createdBy=39a95421810, createdName=ms3000001831800181, createdTime=Tue Sep 29 15:16:37 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026697, encodeId=f402102669e39, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045983, encodeId=ba4a10459834c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], 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    2020-09-30 咻凡

    考虑到非标准化的疾病标准,应考虑进一步设计良好的前瞻性试验以证实这些结果。

    0

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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=)]
    2020-09-29 盒子大人5034

    好文章

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200926/6acfc563dea348a49bf7592d1da41432/dbd5d140356a4140b7a0a2aee769926f.jpg, createdBy=39a95421810, createdName=ms3000001831800181, createdTime=Tue Sep 29 15:16:37 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026697, encodeId=f402102669e39, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045983, encodeId=ba4a10459834c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=)]
    2020-09-29 ms3000001831800181

    了解了

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200926/6acfc563dea348a49bf7592d1da41432/dbd5d140356a4140b7a0a2aee769926f.jpg, createdBy=39a95421810, createdName=ms3000001831800181, createdTime=Tue Sep 29 15:16:37 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026697, encodeId=f402102669e39, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045983, encodeId=ba4a10459834c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=)]
    2020-09-29 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200926/6acfc563dea348a49bf7592d1da41432/dbd5d140356a4140b7a0a2aee769926f.jpg, createdBy=39a95421810, createdName=ms3000001831800181, createdTime=Tue Sep 29 15:16:37 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026697, encodeId=f402102669e39, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045983, encodeId=ba4a10459834c, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Sep 29 12:37:44 CST 2020, time=2020-09-29, status=1, ipAttribution=)]
    2020-09-29 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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