NEJM:利伐沙班用于下肢骨科整形手术后静脉血栓预防

2020-05-14 MedSci原创 MedSci原创

在下肢非主要骨科整形手术后,利伐沙班预防静脉血栓的效果优于依诺肝素

非主要下肢骨科整形手术会导致患者行动能力短暂下降,甚至发生静脉血栓栓塞,而利伐沙班的预防效果可能与依诺肝素相当。
 
近日,研究人员招募下肢非主要骨科整形手术成人患者,随机接受利伐沙班或者依诺肝素。研究的主要终点为有症状的远端或近端深静脉血栓形成、肺栓塞、静脉血栓栓塞相关死亡或无症状的近端深静脉血栓。
 
3604名患者参与研究,其中1809名接受利伐沙班治疗,1795名接受依诺肝素治疗。利伐沙班组1661例患者中有4例(0.2%),依诺肝素组1640例患者中有18例(1.1%)发生大静脉血栓栓塞(多重风险比0.25)。利伐沙班组和依诺肝素组出血发生率无显著性差异(主要出血或非主要临床相关出血率分别为1.1%和1.0%,而主要出血率分别为0.6%和0.7%)。
 
研究认为,在下肢非主要骨科整形手术后,利伐沙班预防静脉血栓的效果优于依诺肝素。
 
原始出处:
 
C. Marc Samama et al. Rivaroxaban or Enoxaparin in Nonmajor Orthopedic Surgery. N Engl J Med,May 14,2020.

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    2020-10-05 fusion
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    2020-12-18 xue8602
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    2020-05-14 卤爪爪

    涨知识

    0

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    2020-05-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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