JACC:进行性恶化心衰的临床特征研究

2019-02-28 不详 MedSci原创

进行性恶化的心衰伴射血分数降低(HFrEF)患者的流行病学特征尚不完整。本研究的目的旨在评估进行性恶化的HFrEF患者的发病率、临床特征、治疗和预后。本研究纳入分析了11064名HFrEF患者,其中1851名(17%)患者在平均1.5年后发展为进行性恶化的HFrEF患者。发展为进行性恶化的HFrEF患者更多的是非洲裔美国人,年龄多在80-90岁之间,并发症的负担更高(p < 0.001)。在

进行性恶化的心衰伴射血分数降低(HFrEF)患者的流行病学特征尚不完整。本研究的目的旨在评估进行性恶化的HFrEF患者的发病率、临床特征、治疗和预后。

本研究纳入分析了11064名HFrEF患者,其中1851名(17%)患者在平均1.5年后发展为进行性恶化的HFrEF患者。发展为进行性恶化的HFrEF患者更多的是非洲裔美国人,年龄多在80-90岁之间,并发症的负担更高(p < 0.001)。在进行性恶化HF形成后,42.4%的患者接受的是单一疗法,43.4%的患者接受的是双重疗法,14.1%的患者接受的是三重疗法。总共48%、61%和98%的患者分别接受了血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂、β受体阻滞剂和盐皮质激素受体拮抗剂的目标剂量>50%的治疗。另外,患者2年的死亡率是22.5%,56%的患者在发展为进行性恶化HF的30天内再住院治疗。

研究结果显示,有约六分之一的心衰伴射血分数降低的患者会在诊断后18个月内发展为进行性恶化的心衰,这些患者的2年死亡率和再住院风险明显更高。

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    2019-10-12 hbwxf
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  5. 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    2019-03-01 Y—xianghai

    学习了长知识

    0

  6. 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    2019-03-01 Y—xianghai

    学习了新知识

    0

  7. 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    2019-03-01 Y—xianghai

    学习了长知识

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  8. 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likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Mar 01 07:02:45 CST 2019, time=2019-03-01, status=1, ipAttribution=)]
    2019-03-01 Y—xianghai

    学习了新知识

    0

  9. 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    2019-03-01 Y—xianghai

    学习了长知识

    0

  10. 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    2019-03-01 Y—xianghai

    学习了新知识

    0

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如果把人体比作社会,身体内的每个细胞就好像社会中的成员。为了维护“社会”的和谐稳定,每个体细胞成员都各司其职,它们被训练得高度“专业”,以适应自己的功能。

JAHA:二尖瓣反流对运动耐量的影响研究

二尖瓣反流(MR)是影响运动耐量的一个潜在因素,目前尚不清楚这是由于反流本身还是瓣膜功能不全导致的。本研究纳入了3267名接受了运动平板心肌灌注成像和经胸超声心动图检查的患者,其中28%的患者有MR,包括176名(5%)患者有中重度的MR。MR患者的左室收缩功能明显降低,心室的大小明显增加,伴随着心肌灌注不足的增加(P<0.001)。患者的运动耐量随着MR严重程度的增加而逐级递减(P<

JAHA:国人学者揭示抑郁可增加心梗患者不良预后风险

非阻塞性冠脉心梗(MINOCA)占到心梗患者的约10%,目前尚缺乏抑郁对MINOCA预后影响的研究。本研究的目的旨在评估抑郁对中国MINOCA患者预后的影响。本研究纳入了633例MINOCA患者,并随访了3年,终点事件为全因死亡率和心血管事件。在随访期间,有93例患者发生全因死亡事件,170例患者发生不良心血管事件。 Kaplan-Meier 曲线结果显示抑郁与全因死亡率和心血管事件均呈明显相关性