JACC:出院后出血与急性心梗患者死亡率相关

2020-07-12 MedSci原创 MedSci原创

在未经皮冠状动脉介入治疗(PCI)的急性冠脉综合征(ACS)患者中,出院后出血的长期预后影响尚不清楚。本研究的目的是根据治疗策略(PCI或非PCI)评估ACS患者出院后出血与随后死亡率之间的关系。

在未经皮冠状动脉介入治疗(PCI)的急性冠脉综合征(ACS)患者中,出院后出血的长期预后影响尚不清楚。本研究的目的是根据治疗策略(PCI或非PCI)评估ACS患者出院后出血与随后死亡率之间的关系。

本研究纳入分析了来自4个多中心临床研究中的45011名患者,其中1133名在出院后出现了出血事件,2149名患者死亡。出血后<30天(校正危险比:15.7;95%置信区间:12.3~20.0)和30~12个月(校正危险比:2.7;95%置信区间:2.1~3.4)的死亡率显着增高,在接受或不接受PCI治疗的受试者中,这种相关性是一致的。另外,出院后出血与死亡率之间的时间相关关系与接受PCI和未经PCI治疗的患者的心梗和随后死亡率之间的关联相似。

研究结果显示,急性冠脉综合征后的出院后出血与接受PCI或未经PCI治疗的患者的后续全因死亡率增加相关。

原始出处:

Guillaume M et al.Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI.JACC.2020 July.

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    2020-09-10 hbwxf
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