Lancet Diabetes and Endocrinology:这些物质正在摧毁健康,引发肥胖、不孕不育、癌症等问题

2020-07-25 探索菌 生物探索

狄更斯在世界名着《双城记》的开头写道,“这是最好的时代,这是最坏的时代。”在科学技术飞速发展的今天,人们的生活越来越便利,但是生活环境却越来越糟,各种疾病和灾难更加频繁地出现。

狄更斯在世界名着《双城记》的开头写道,“这是最好的时代,这是最坏的时代。”在科学技术飞速发展的今天,人们的生活越来越便利,但是生活环境却越来越糟,各种疾病和灾难更加频繁地出现。与百十年前相比,我们似乎正生活在一个更加恶劣的世界,各类化学合成物质的广泛使用似乎正在改变着我们的体质,摧毁着我们的健康。


当地时间7月21日,《柳叶刀糖尿病和内分泌学》(The Lancet Diabetes and Endocrinology)发布的一篇文章全面揭示了在工业和家庭用品中常见的化学合成物质及其对人类健康的影响。


这支由纽约大学格罗斯曼医学院的研究人员领导的国际研究团队,分析了过去5年里有关环境内分泌干扰物的研究后发现,在不粘锅、防水衣服、塑料瓶等物品含有的化学物质可能会循环影响整个人体,造成包括不孕不育、糖尿病、大脑发育、肥胖等多种疾病。


环境内分泌干扰物摧毁健康


环境内分泌干扰物(EDC),也被称为环境激素,主要是指在人类的生产和生活活动中排放到环境中的有机污染物。常见的EDC包括全氟烷基物质(PFAS)、双酚类化合物、邻苯二甲酸盐、有机磷农药等,这些物质进入人体后能够影响内分泌系统功能。目前,EDC被公认是全球潜在的主要环境风险之一。


2015年,由联合国和世界卫生组织领导的一份联合调查已经确定了15种传统化合物的EDC暴露及相关影响之间的关联程度。


在此基础上,这项新研究重点关注与目前常用的合成化学品相关的研究报告,并确定了一系列与围产期、神经发育、新陈代谢以及生殖结果等关联的EDC暴露及结局。


常见的EDC暴露及后果


全氟烷基物质(PFAS)是一组人造化学品,常被用于不粘类产品、抛光剂、油漆、防水织物等物质中。在对该系列研究文献进行分析后,研究人员发现,PFAS暴露似乎与儿童和成人的肥胖、糖耐量受损、妊娠期糖尿病、出生体重减少、精液质量下降、多囊卵巢综合征、子宫内膜异位症和乳腺癌密切关联。


双酚类化合物常作为增塑剂、抗氧剂、热稳定剂等添加剂应用于塑料、纸币、热敏纸等日常用品中。有证据表明,这类物质的暴露与成人糖尿病、精液质量下降、多囊卵巢综合征等密切相关。


邻苯二甲酸盐是常见的增塑剂,在塑料和油漆中普遍存在。该类物质的暴露与孕妇早产、男性不育及生殖力降低、儿童肥胖和葡萄糖耐量受损等相关。


另外,有机磷农药的暴露与男性精液质量下降、前列腺癌、乳腺癌的发生有关,产前暴露于有机磷农药则与婴儿智商下降和智障、注意力缺陷多动障碍(ADHD)等密切相关。


该报告的主要作者之一、纽约大学朗格健康学院儿科系博士后Linda Kahn表示:“这些新发现加强了将EDC与身体,尤其是神经系统健康问题联系起来的证据。尽管仍需进一步研究以进一步确定EDC暴露与健康问题的因果关系,但现在应该采取紧急行动,我们的公众已经为严重和长期的健康问题消耗了太多。”

 

原始出处:

Linda GKahnPhDa,ClairePhilippatPhDc,Shoji FNakayamaPhDd,et al.Endocrine-disrupting chemicals: implications for human health.The Lancet Diabetes & Endocrinology.Volume 8, Issue 8, August 2020, Pages 703-718

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  5. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 12:25:52 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
  6. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 12:25:52 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

  7. 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  8. 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topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 19 07:45:16 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902466, encodeId=5b60190246687, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Dec 07 02:45:16 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813724, encodeId=317d813e24e6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:02:02 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355091, encodeId=8e80135509167, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 27 01:45:16 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804605, encodeId=7588804605b0, content=环境治理刻不容缓了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Jul 26 14:44:40 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033902, encodeId=ff2b103390263, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 25 13:45:16 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804505, encodeId=d0d48045050d, content=影响可能远远不止这些, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 12:25:52 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
    2020-07-26 彭红

    环境治理刻不容缓了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1830758, encodeId=fbff1830e5851, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed May 12 12:45:16 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761458, encodeId=dd9b1e61458c5, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Oct 04 14:45:16 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785218, encodeId=5b671e852187e, content=<a href='/topic/show?id=4c2a6e614a' target=_blank style='color:#2F92EE;'>#Endocrinology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6761, encryptionId=4c2a6e614a, topicName=Endocrinology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Mon Aug 03 11:45:16 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639535, encodeId=5e08163953596, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 19 07:45:16 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902466, encodeId=5b60190246687, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Dec 07 02:45:16 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813724, encodeId=317d813e24e6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:02:02 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355091, encodeId=8e80135509167, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 27 01:45:16 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804605, encodeId=7588804605b0, content=环境治理刻不容缓了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Jul 26 14:44:40 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033902, encodeId=ff2b103390263, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 25 13:45:16 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804505, encodeId=d0d48045050d, content=影响可能远远不止这些, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 12:25:52 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
    2020-07-25 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1830758, encodeId=fbff1830e5851, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed May 12 12:45:16 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761458, encodeId=dd9b1e61458c5, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Oct 04 14:45:16 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785218, encodeId=5b671e852187e, content=<a href='/topic/show?id=4c2a6e614a' target=_blank style='color:#2F92EE;'>#Endocrinology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6761, encryptionId=4c2a6e614a, topicName=Endocrinology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Mon Aug 03 11:45:16 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639535, encodeId=5e08163953596, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Mar 19 07:45:16 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902466, encodeId=5b60190246687, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Dec 07 02:45:16 CST 2020, time=2020-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813724, encodeId=317d813e24e6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:02:02 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355091, encodeId=8e80135509167, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 27 01:45:16 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804605, encodeId=7588804605b0, content=环境治理刻不容缓了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200726/689f5dfb6e5b4165b1a5156604f91964/518e32492fdf40689b7cc8c73fa0f600.jpg, createdBy=cc9a5402881, createdName=彭红, createdTime=Sun Jul 26 14:44:40 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033902, encodeId=ff2b103390263, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 25 13:45:16 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804505, encodeId=d0d48045050d, content=影响可能远远不止这些, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 12:25:52 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
    2020-07-25 1240394fm61暂无昵称

    影响可能远远不止这些

    0

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