Diabetes Care:空腹血糖、餐后血糖和血红蛋白A1c对中国成人糖尿病及并发症风险的预测价值

2019-06-03 xing.T 网络

由此可见,2h-PG仍可独立预测包括FPG和HbA1c在内的模型的结局。因此,除了FPG和HbA1c之外,还应考虑2h-PG的常规检测,以便更好地评估结局风险。

关于各种血糖指标的预测价值仍存在不确定性,因为它们与糖尿病及其并发症的风险有关。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员使用美国糖尿病协会2010年标准推荐的临界值确定了空腹血糖(FPG)、2小时餐后血糖(2h-PG)和HbA1c与结局之间的关系。

研究人员从2011-2012年中国≥38岁的193846名成年人群中获得了基线病史、FPG、2h-PG和HbA1c。2014-2016年期间进行了一次随访,以评估糖尿病、血管疾病(CVD)、癌症和死亡率。 

在随访5年期间,研究人员记录了8063例糖尿病,3014例CVD相关事件,1624例癌症和2409例死亡。基于FPG为100-125 mg/dL、2h-PG为140-199mg/dL或HbA1c为5.7-6.4%(39-47mmol/mol)的糖尿病前期相关糖尿病的多变量调整风险比(95%CI)分别为1.60(1.43-1.79)、2.72(2.43-3.04)和1.49(1.36-1.62)。限制性三次样条曲线分析表明FPG、2h-PG和HbA1c水平与CVD、癌症和死亡率的J形关联。基于FPG≥126mg/dL、2h-PG≥200mg/dL或HbA1c≥6.5%(48mmol/mol)的未治疗糖尿病相关的CVD多变量校正风险比(95%CI)分别为1.18(1.05-1.33)、1.31(1.18-1.45)和1.20(1.07-1.34); 癌症风险比分别为1.10(0.92-1.32)、1.44(1.25-1.67)和1.08(0.92-1.28);死亡率分别为1.37(1.20-1.57)、1.57(1.41-1.76)和1.33(1.17-1.52)。包括FPG和HbA1c作为样条项的模型中2h-PG与结果显著相关。此外,2h-PG显著提高了预测糖尿病、CVD和死亡率能力的C统计量。 

由此可见,2h-PG仍可独立预测包括FPG和HbA1c在内的模型的结局。因此,除了FPG和HbA1c之外,还应考虑2h-PG的常规检测,以便更好地评估结局风险。 

原始出处:


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    2019-06-04 枫三仨个牛

    学习学习学习学习学习

    0

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