Neurology:自身抗体及补体途径在免疫坏死性肌病中发挥重要作用

2018-01-14 zhangfan MedSci原创

研究发现了抗SRP和抗HMGCR抗体在免疫介导坏死性肌病中的作用,强调体液机制是免疫和肌纤维坏死的关键因素

近日,研究人员利用抗信号识别粒子(SRP)或抗3-羟基-3-甲基戊二酰辅酶(Hmgcr)抗体表征免疫介导坏死性肌病(IMNM)中的肌纤维坏死,并探讨其潜在的分子免疫机制。

研究人员采集IMNM患者及肌炎对照患者的肌肉切片进行分析比较,采用免疫染色和反转录PCR考察肌肉样本,在体外对骨骼肌细胞进行免疫组化染色。

研究发现,肌酸激酶水平、肌肉组织再生能力与坏死纤维比例相关(r = 0.6, p < 0.001)。CD68+iNOS+巨噬细胞以及Th-1免疫环境在持续的坏死纤维噬肌过程中发挥作用。T细胞密度与坏死相关,但未发现细胞毒性迹象。坏死过程存在补体级联经典通路的激活,伴随着免疫球蛋白沉积,提示体液免疫参与。当组织样本与纯化后患者肌管自身衍生抗体培养后,肌纤维蛋白表现出SRP和HMGCR特征。肌层补体沉积与纤维坏死存在相关性(r = 0.4;p = 0.004)。

研究发现了抗SRP和抗HMGCR抗体在免疫介导坏死性肌病中的作用,强调体液机制是免疫和肌纤维坏死的关键因素。

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    2018-06-27 yinhl1978
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    2018-01-24 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 14 09:15:40 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-01-15 millore
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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 14 09:15:40 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-01-14 惠映实验室

    学习了.谢谢.

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 14 09:15:40 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-01-14 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 14 10:18:26 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278370, encodeId=b7602e83700b, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Jan 14 09:18:30 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278363, encodeId=f6032e8363b2, content=学习了.谢谢分享, beContent=null, 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    2018-01-14 飛歌

    学习了很有用

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 14 09:15:40 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-01-14 龙胆草

    学习谢谢分享

    0

  10. 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    2018-01-14 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0