J Clin Periodontol:唾液生物标志物可以鉴别II型糖尿病患者是否患有牙周炎

2021-07-08 MedSci原创 MedSci原创

唾液中的生物标志物可以帮助评估牙周炎;然而,在存在糖尿病的情况下,其浓度可能会发生改变。本文中,研究人员探究了唾液生物标志物对牙周健康的II型糖尿病患者(T2DM)和患有牙周炎的T2DM的鉴别能力,结

唾液中的生物标志物可以帮助评估牙周炎;然而,在存在糖尿病的情况下,其浓度可能会发生改变。本文中,研究人员探究了唾液生物标志物对牙周健康的II型糖尿病患者(T2DM)和患有牙周炎的T2DM的鉴别能力,结果已发表于J Clin Periodontol。

研究共纳入92名参与者(29名患有慢性牙周炎的T2DM,DWP;32名没有慢性牙周炎的T2DM,DWoP;以及31名没有牙周炎的参与者,NP),收集唾液并记录牙周健康的临床参数。通过免疫测定测量唾液中白细胞介素(IL)-1β、IL-6、基质金属蛋白酶-8(MMP-8)、巨噬细胞炎症蛋白-1α(MIP-1α)、脂肪素和抵抗素的浓度。

 

结果显示,唾液中IL-1β、MMP-8和抵抗素的浓度与牙周炎的临床参数相关,其中MMP-8与PD≥5 mm显示出最强的正相关(P < 0.0001)。牙周健康反映在各组的唾液分析物浓度中,IL-1β和MMP-8的浓度与牙周炎密切相关(P≤0.04),从健康到DWoP到DWP的浓度增加。OR分析显示,MMP-8可识别NP(OR为8.12;95% CI:1.01-65.33;p = 0.03)和T2DM(DWP vs DWoP,OR = 5.09;95% CI:1.24-20.92;p = 0.03)患者中牙周炎的存在与否。

综上,该研究结果表明,唾液中的MMP-8和IL-1β可以鉴别T2DM的牙周炎。

 

原始出处:

 

Craig S Miller, et al.,Salivary biomarkers for discriminating periodontitis in the presence of diabetes. J Clin Periodontol. 2021 Feb;48(2):216-225. doi: 10.1111/jcpe.13393.   

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    2021-07-09 face

    有意思

    0

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    2021-07-08 misszhang

    谢谢MedSci提供最新的资讯

    0

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