Circulation:肤色竟影响冠心病患病风险!

2017-07-14 cacailingrui MedSci原创

总体来说,考虑了社会性的和其他影响健康的风险因素之后,黑人和白人在致死性冠心病方面的风险几乎没有什么差异。但是,在非致死性心脏病方面,黑人男性和女性都有较低的风险。

我们通常认为,黑人有比白人更高的冠心病 (coronary heart disease,CHD) 死亡率。然而,曾有研究表明在非致死性冠心病方面,黑人男性比白人男性患病风险更低一些。 

最近这项研究按性别区分并比较了来自社区人群动脉粥样硬化发病风险研究 (Atherosclerosis Risk in Communities study,ARIC), 心血管健康研究(Cardiovascular Health Study,CHS)和卒中地理和种族差异的原因研究 (Reasons for Geographic and Racial Differences in Stroke study,REGARDS)的致死性和非致死性冠心病的发病率和病死率。45-64岁的参与者来自ARIC(男性6479名,女性8848名)和REGARDS(男性5296名,女性7822名),65岁及以上的参与者来自CHS(男性1836名,女性2790名)和REGARDS(男性3381名,女性4112名),所有参与者在这之前都没有过冠心病的发病史。从研究开始到随后的11年间,坚持对每个参与者随访并记录冠心病的发病情况,从而计算总的发病率。

对来自ARIC和REGARDS研究中的45-64岁男性参与者进行统计,并就年龄因素进行校正,就致死性冠心病而言,黑人男性风险比为2.09(95%CI,1.42-3.06),白人男性风险比为2.11(95%CI,1.32-3.38),对于非致死性惯性并,黑人男性风险比为0.82 (95%CI,0.64–1.05) ,而白人男性为0.94 (95%CI,0.69–1.28)。根据社交决定的健康和心血管风险因子等对数据进行校正后,致死性冠心病的风险比分别为1.19 (95% CI, 0.74–1.92) 和1.09 (95% CI,0.62–1.93), 非致死性冠心病的风险比为0.64 (95% CI,0.47–0.86) 和 0.67 (95% CI,0.48–0.95)。类似的情况也出现在65岁及以上的CHS和REGARDS组中。

研究人员同样对女性群体做了对应的统计,经年龄因素校正后,ARIC和REGARDS研究中45-64岁女性黑人和白人的致死性冠心病风险比为2.61 (95% CI, 1.57–4.34) 和 1.79 (95% CI, 1.06–3.03)。对非致死性冠心病来说,风险比分别为1.47 (95% CI, 1.13–1.91) 和 1.29 (95% CI, 0.91–1.83)。在经过多种变量校正后,致死性冠心病风险比分别为0.67 (95% CI, 0.36–1.24) 和 1.00 (95% CI, 0.54–1.85), 非致死性冠心病风险比分别为0.70 (95% CI, 0.51–0.97) 和 0.70 (95% CI, 0.46–1.06)。种族差异对于冠心病发生率的影响在老年女性中已不明显。冠心病在黑人中的致死率高于白人,在经过多重变量调整后,这种差异依然存在。 

总体来说,考虑了社会性的和其他影响健康的风险因素之后,黑人和白人在致死性冠心病方面的风险几乎没有什么差异。但是,在非致死性心脏病方面,黑人男性和女性都有较低的风险。 


原始出处:
Lisandro D. Colantonio, et al. Black-White Differences in Incident Fatal, Nonfatal, and Total Coronary Heart Disease. Circulation. 2017;136:152-166
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Aug 07 10:22:28 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-26 130****4638

    学习了谢谢分享

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Aug 07 10:22:28 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-24 130****4638

    学习了谢谢分享

    0

  5. 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    2017-08-21 189****7206

    学习了受益匪浅

    0

  6. 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    2017-08-18 189****7206

    学习了谢谢分享

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Aug 07 10:22:28 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-16 184****9840

    学习了受益匪浅

    0

  8. 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    2017-08-11 184****9840

    学习了谢谢分享

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Aug 07 10:22:28 CST 2017, time=2017-08-07, status=1, ipAttribution=)]
    2017-08-09 184****9840

    学习了受益匪浅

    0

  10. 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