Semin Arthritis Rheu:免疫抑制剂治疗的风湿病患者感染COVID-19的特征

2020-06-23 xiangting MedSci原创

RD患者容易感染COVID-19。不同的DMARDs或生物制剂会不同程度影响病毒感染的进程。使用羟氯喹、TNFα拮抗剂或托珠单抗的患者病情较轻。

这项研究旨在分析使用免疫抑制剂治疗的风湿性疾病(RD)患者感染COVID-19的临床特征和预后。

通过回顾性病历审查研究了一系列使用疾病改善抗风湿药物(DMARDs)治疗并感染COVID-19的RD患者。文献检索确定了9个类似的单病例和病例系列研究,也被纳入该研究。

作者所在医院有4例感染COVID-19 的RD住院患者,平均年龄57±21岁。2例患者为轻度感染,2例出现严重COVID-19相关性呼吸系统并发症,其中1例使用苏金单抗的患者需要机械通气,1例使用利妥昔单抗的患者出现需要补充氧合的病毒性肺炎。4例患者的急性期反应物均升高,2例轻度COVID-19患者淋巴细胞减少,2例重症COVID-19患者淋巴细胞计数正常,而IL-6水平升高。没有患者出现RD恶化。在文献中,9项COVID-19研究包括197例各种炎症性RD患者。大多数患者使用DMARDs或生物制剂治疗,其中最常用的是TNFα抑制剂。2例使用托珠单抗治疗的患者为轻度感染。2例使用利妥昔单抗治疗的患者中,1例为重症COVID-19需要机械通气。6例使用苏金单抗治疗的患者中,1例住院。全部201个病例中,12例死亡,估算死亡率为5.9%

RD患者容易感染COVID-19。不同的DMARDs或生物制剂会不同程度影响病毒感染的进程。使用羟氯喹、TNFα拮抗剂或托珠单抗的患者病情较轻。利妥昔单抗或苏金单抗可能使病毒感染恶化。需要进一步的研究。

原始出处:

Saika Sharmeen. COVID-19 in rheumatic disease patients on immunosuppressive agents. Semin Arthritis Rheu. August 2020.

 

 

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    2021-05-20 jklm09
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    2020-06-25 zhaojie88

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