Circulation:预防痴呆?可能要从娃娃抓起!

2021-05-13 MedSci原创 MedSci原创

随着人口老龄化的深入进展,预防老年人认知功能障碍显得越来越重要。

随着人口老龄化的深入进展,预防老年人认知功能障碍显得越来越重要。其中,亚临床认知障碍,例如记忆、学习和决策方面的减退,可能在认知障碍达到临床可检测水平之前几十年就出现了。

目前有关认知障碍发生的公认风险因素包括教育程度低、高血压、肥胖、2型糖尿病、吸烟、缺乏锻炼、不良饮食习惯以及抑郁症等。以前关于血管危险因素(CVRF)的观察性研究的结果主要集中在中年人,而只有少数研究是从成年早期开始的。

值得注意的是,随着年龄增加,CVRF的作用往往会累积。以前的研究主要集中在个体CVRF暴露的影响上,而很少有研究集中在CVRF累积与认知表现或痴呆症风险之间的联系上。同时,仅有少数具有成年期数据的研究集中在纵向测量的成年期CVRF累积对认知的影响。

因此,来自芬兰图尔库大学应用和预防心血管医学研究中心的专家假设,自童年以来CVRF的纵向积累可能与自童年以来的认知表现有关,并开展了相关研究。结果发表在最新的《循环》Circulation杂志上。

从1980年开始,一个由3596名儿童(3-18岁)组成的基于人群的队列被反复随访了31年。在每次随访中,研究人员都评估了参与者的血压、血脂和体重指数(BMI)。从童年到中年的CVRF轨迹是使用潜在的阶层增长混合模型确定的。认知测试在2026名年龄在34-49岁的参与者中使用计算机化测试进行。针对个体CVRF和CVRF累积,研究了CVRF轨迹和认知表现之间的联系。

收缩压 (A)、血清总胆固醇(B)和体重指数(C)从童年到中年的轨迹

结果显示,与持续的低值相比,持续的高收缩压(β=–0.262)和血清总胆固醇(β=–0.214)与中年时期情节记忆和联想学习能力更差相关。与正常体重相比,儿童时期的肥胖与视觉处理和持续注意力更差有关(β=–0.407)。

同时,研究人员还观察到CVRF累积与情节记忆和联想学习 (3个CVRFs:β=–0.390)、视觉处理和持续注意力(3个CVRFs:β=–0.443)以及反应力和运动时间(2个CVRFs:β=–0.164 SD[95%置信区间,–0.318至–0.010]) 均呈负相关。

心血管危险因素评分组的描述性特征

为此,研究人员指出,从童年到中年,纵向收缩压升高、高血清总胆固醇和肥胖与中年认知能力呈负相关。值得注意的是,心血管危险因素的数量越多,中年时的认知表现越差。

因此,从儿童时期就开始针对心血管危险因素采取预防策略,可能有利于在成年期从根本上促进认知健康。

 

参考文献:

Cardiovascular Risk Factor Trajectories Since Childhood and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study. https://doi.org/10.1161/CIRCULATIONAHA.120.052358

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1820166, encodeId=617d1820166c2, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Feb 21 21:50:00 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967121, encodeId=ccc996e12173, content=预防痴呆,从小做起, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Thu May 20 05:47:40 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965546, encodeId=b73d965546c8, content=从**时期抓起, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e8b5499394, createdName=风在发端35, createdTime=Fri May 14 14:16:44 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048787, encodeId=51301048e871c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri May 14 01:50:00 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965375, encodeId=37f59653e5aa, content=<a href='/topic/show?id=0bf94e52dc' target=_blank style='color:#2F92EE;'>#Circulation#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4752, encryptionId=0bf94e52dc, topicName=Circulation)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 13 23:03:25 CST 2021, time=2021-05-13, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1820166, encodeId=617d1820166c2, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Feb 21 21:50:00 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967121, encodeId=ccc996e12173, content=预防痴呆,从小做起, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Thu May 20 05:47:40 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965546, encodeId=b73d965546c8, content=从**时期抓起, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e8b5499394, createdName=风在发端35, createdTime=Fri May 14 14:16:44 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048787, encodeId=51301048e871c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri May 14 01:50:00 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965375, encodeId=37f59653e5aa, content=<a href='/topic/show?id=0bf94e52dc' target=_blank style='color:#2F92EE;'>#Circulation#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4752, encryptionId=0bf94e52dc, topicName=Circulation)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 13 23:03:25 CST 2021, time=2021-05-13, status=1, ipAttribution=)]
    2021-05-20 124292adm29暂无昵称

    预防痴呆,从小做起

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1820166, encodeId=617d1820166c2, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Feb 21 21:50:00 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967121, encodeId=ccc996e12173, content=预防痴呆,从小做起, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Thu May 20 05:47:40 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965546, encodeId=b73d965546c8, content=从**时期抓起, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e8b5499394, createdName=风在发端35, createdTime=Fri May 14 14:16:44 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048787, encodeId=51301048e871c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri May 14 01:50:00 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965375, encodeId=37f59653e5aa, content=<a href='/topic/show?id=0bf94e52dc' target=_blank style='color:#2F92EE;'>#Circulation#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4752, encryptionId=0bf94e52dc, topicName=Circulation)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 13 23:03:25 CST 2021, time=2021-05-13, status=1, ipAttribution=)]
    2021-05-14 风在发端35

    从**时期抓起

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1820166, encodeId=617d1820166c2, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Feb 21 21:50:00 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967121, encodeId=ccc996e12173, content=预防痴呆,从小做起, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Thu May 20 05:47:40 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965546, encodeId=b73d965546c8, content=从**时期抓起, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e8b5499394, createdName=风在发端35, createdTime=Fri May 14 14:16:44 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048787, encodeId=51301048e871c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri May 14 01:50:00 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965375, encodeId=37f59653e5aa, content=<a href='/topic/show?id=0bf94e52dc' target=_blank style='color:#2F92EE;'>#Circulation#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4752, encryptionId=0bf94e52dc, topicName=Circulation)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 13 23:03:25 CST 2021, time=2021-05-13, status=1, ipAttribution=)]
    2021-05-14 junJUN

    老年人痴呆何药可用??

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1820166, encodeId=617d1820166c2, content=<a href='/topic/show?id=97011003512e' target=_blank style='color:#2F92EE;'>#预防痴呆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100351, encryptionId=97011003512e, topicName=预防痴呆)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Mon Feb 21 21:50:00 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967121, encodeId=ccc996e12173, content=预防痴呆,从小做起, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Thu May 20 05:47:40 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965546, encodeId=b73d965546c8, content=从**时期抓起, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2e8b5499394, createdName=风在发端35, createdTime=Fri May 14 14:16:44 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048787, encodeId=51301048e871c, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri May 14 01:50:00 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965375, encodeId=37f59653e5aa, content=<a href='/topic/show?id=0bf94e52dc' target=_blank style='color:#2F92EE;'>#Circulation#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4752, encryptionId=0bf94e52dc, topicName=Circulation)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 13 23:03:25 CST 2021, time=2021-05-13, status=1, ipAttribution=)]

拓展阅读

IJNS:基于生命历程模型的多领域干预可降低老年人痴呆的风险

基于生命历程模型的多领域干预是可行的,有可能降低中国高危老年人患痴呆症的风险,改善他们的认知功能。

ART:视网膜血管的变化有望为观测阿尔茨海默病进程提供一个窗口

视网膜血管测量并不能代表非痴呆个体的脑血管损伤,而鼻侧象限的VD与海马萎缩相关,与淀粉样蛋白状态无关。

Neurology:利用基于弥散的神经炎症成像技术研究阿尔茨海默病的白质神经炎症

WM神经炎症在AD临床症状出现之前就已发生改变,并且与淀粉样变性相互作用。

Nature子刊:与记忆力训练相比,瑜伽对老年痴呆高危妇女的认知和免疫学影响

KY 对 SCD 有临床和生物学上的益处,将认知的变化与瑜伽的抗炎作用联系起来。

BMJ子刊:心血管风险负担、痴呆症风险和大脑结构成像标记——英国生物数据库研究

心血管风险负担与痴呆风险的正相关关系也适用于主要的痴呆亚型。心血管风险负担与全因痴呆的关系在很大程度上与心血管疾病的发病和痴呆的遗传易感性无关。

IJNS:老年痴呆症患者营养不良患病率和营养不良风险

结果表明,大约三分之一的痴呆症老年人存在营养不良,近一半的老年人有营养不良的风险。