Clin Nutrition: 住院时的营养风险与新冠肺炎老年患者的住院时间延长有关

2021-11-24 MedSci原创 MedSci原创

营养风险概念的 一个重要特征是“营养风险与临床结局(outcome)密切相关”。只有改善临床结 局才能使患者真正受益,即改善临床结局是临床营养支持的终点(endpoint)。

众所周知,营养不良是老年住院患者中非常普遍的疾病,在入院的老年患者中存在高达一半,并与生活功能下降、死亡率增加、住院时间延长 (LOS) 和再住院率增加相关。随着对老年人群新型冠状病毒病感染 (COVID-19) 认识的加深,老年患者已被确定为新冠病毒感染、不良结局和死亡率的高危人群。营养不良与感染存在相关性,因为营养不良的患者感染并发症的风险增加,而急性疾病会迅速恶化营养状况。营养状况不佳会损害免疫反应并降低治疗效果,从而导致更高的发病率。本项研究旨在探究老年 COVID-19 患者入院时的营养风险与住院时间 (LOS) 和死亡率的关联。

 

本项研究是一项回顾性单中心研究,研究人员广泛收集了所有受试者的医疗记录,并根据营养风险筛查 (NRS) 评估患者的营养风险,然后使用单变量和多变量(根据年龄、性别和合并症负担调整)Cox 比例风险和线性回归模型来评估上述结果的之间的关联。

 

在总共245名患者(平均年龄:86.1±6.4岁)中,50.6% 的患者在入院时有严重的营养不良风险(NRS≥5/7)。较低的 BMI、认知障碍和吞咽障碍在 NRS 较高的患者中更为普遍。NRS≥5与死亡率无关,173名患者的 LOS 延长了3天以上(β:3.69;0.71–6.67 95% CI;p=0.016),出院率延迟了1.8倍(HR 0.55; 0.37–0.83 95% CI;p = 0.101)。

本项研究证实在因COVID-19感染住院的老年患者中,入院时营养不良风险NRS≥5与更长的 LOS 相关,但与死亡率无关。

原始出处:

AlineMendes. Et al. Nutritional risk at hospital admission is associated with prolonged length of hospital stay in old patients with COVID-19. Clinical Nutrition.2021.

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    2021-11-24 onebutton

    学习了

    0

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    2021-11-24 yangchou

    好文章,值得一读。

    0

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    2021-11-24 ms7000001163334588

    #房颤#学习了

    0

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