体外受精-胚胎移植后双侧输卵管异位妊娠1 例

2020-01-09 冯振华 曹晓航 现代妇产科进展

患者,女, 31 岁, G3P0,因“胚胎移植后第32 天,阴道流血10+天”就诊于我院。患者9 年前有异位妊娠史,曾接受甲氨蝶呤 注射治疗, 1 年前有自发流产病史。患者 1 个月前于外院行体外受精胚胎移植,移植后第 12 天、第 14 天、第 21 天、第 24 天血 β-HCG 分别为 162mIU/ml、357mIU/ml、2547mIU/ml 及 2897mIU/ml。胚胎移植后第 26

患者,女, 31 岁, G3P0,因“胚胎移植后第32 天,阴道流血10+天”就诊于我院。患者9 年前有异位妊娠史,曾接受甲氨蝶呤 注射治疗, 1 年前有自发流产病史。患者 1 个月前于外院行体外受精胚胎移植,移植后第 12 天、第 14 天、第 21 天、第 24 天血 β-HCG 分别为 162mIU/ml、357mIU/ml、2547mIU/ml 及 2897mIU/ml。胚胎移植后第 26 天,患者出现阴道流血,血 β-HCG 为 2295mIU/ml。入院查体:患者下腹部压痛明显,不伴反跳痛或肌紧张,未扪及明显包块。盆腔检查见阴道少量积血,宫颈口关 闭,无宫颈举痛,子宫大小正常,双侧附件区有压痛。超声示:宫内未见妊娠囊,右侧和左侧卵巢旁分别见 2.86cm×2.75cm 和 3. 5cm×1.55cm 大混合性包块,子宫直肠凹陷处有积液。血 β-HCG 为 2236mIU/ml。入院诊断: 双侧输卵管异位妊娠伴破裂出 血? 遂行诊断腹腔镜检查术,术中见子宫直肠凹陷处约 200ml 陈旧积血,子宫大小正常,双侧输卵管壶腹区发现输卵管妊娠 并粘连,双侧卵巢正常。遂行双侧输卵管切除术,手术过程顺利。标本经组织病理学检查,见绒毛和滋养细胞,符合双侧输卵 管异位妊娠诊断。术后第 1 天血 β-HCG 降至 942mIU/ml,术后第 2 天出院。术后 2 周门诊随访,患者血 β-HCG 降至正常。

讨 论

双侧输卵管异位妊娠是一种非常罕见的异位妊娠类型。双侧异位妊娠的发生与辅助生殖技术相关,具体原因 尚不明确,可能与促排卵方案、输卵管异常导致胚胎移稙后逆行至输卵管有关。双侧输卵管妊娠的主要治疗方式有保守治 疗、肌肉注射甲氨蝶呤、异位妊娠部位局部注射甲氨蝶呤和手术治疗。具体治疗方案的选择需综合多方面因素决定,如患者 的临床情况是否稳定、对未来生育的需求以及对治疗方案是否存在禁忌证。本例患者既往有异位妊娠史,临床考虑异位妊娠 伴破裂出血,诊断性腹腔镜结合双侧输卵管切除术是首选治疗方案。经超声检查发现单侧异位妊娠时,不能除外其他部位同 时存在异位妊娠的可能。对于接受辅助生殖技术的患者,更应警愓两个部位异位妊娠的可能性。

参考文献略。

原始出处:

冯振华,曹晓航,体外受精-胚胎移植后双侧输卵管异位妊娠1 例[J],现代妇产科进展,2019,28(11):803.

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