JCEM:糖尿病与带状疱疹风险之间的关联

2021-09-20 MedSci原创 MedSci原创

与一般人群相比,DM患者发生HZ的风险增加。无论年龄大小,都对DM患者接种水痘疫苗,优先考虑老年人和心血管疾病患者。

糖尿病(DM)患者容易受到各种感染。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估DM患者与普通人群相比患带状疱疹(HZ)的风险。

研究人员检索了PubMed、Embase、Cochrane系统评价数据库、Cochrane对照试验中心登记处、护理和相关健康文献的累积索引以及PerioPath数据库,检索时间从数据库成立到2021年1月30日,以获取关于DM患者HZ风险的研究。

两名作者独立筛选了所有确定的文章。相同的两位研究者独立提取了数据,共包括四项病例对照研究和12项队列研究。研究人员使用固定和混合效应模型进行荟萃分析。

在汇总分析中,与普通人群相比,DM患者发生HZ的风险更高(汇总相对风险:1.38,95%置信区间:1.21-1.57)。在按糖尿病类型、年龄和研究设计分层的亚组分析中,结果是一致的。在DM患者中,血管疾病对HZ风险增加具有累加作用(合并相对风险:1.19,95%置信区间:1.11-1.28)。DM患者的年龄与HZ风险之间存在线性剂量反应关系。

由此可见,与一般人群相比,DM患者发生HZ的风险增加。无论年龄大小,都对DM患者接种水痘疫苗,优先考虑老年人和心血管疾病患者。应根据证据更新针对DM患者的水痘疫苗接种政策。

原始出处:

Chun-Ta Huang.et al.Association between Diabetes Mellitus and the Risk of Herpes Zoster: A Systematic Review and Meta-analysis.JCEM.2021.https://doi.org/10.1210/clinem/dgab675

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    2022-07-22 仁者大医
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    2021-10-27 achengzhao
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    2021-09-21 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  5. 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    2021-09-21 小小的丁香花

    糖尿病患者免疫力低下,这样大型的研究方法学习了。#糖尿病#

    0

  6. 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time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053289, encodeId=7bb61053289df, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee641592989, createdName=guoguolijuan, createdTime=Mon Sep 20 16:43:39 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 SR~young海东

    关注富贵病

    0

  7. 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time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053289, encodeId=7bb61053289df, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee641592989, createdName=guoguolijuan, createdTime=Mon Sep 20 16:43:39 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
  8. 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time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053289, encodeId=7bb61053289df, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee641592989, createdName=guoguolijuan, createdTime=Mon Sep 20 16:43:39 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 梨4

    学习了

    0

  9. 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time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053289, encodeId=7bb61053289df, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee641592989, createdName=guoguolijuan, createdTime=Mon Sep 20 16:43:39 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 123eaf1bm35暂无

    学习了,受益匪浅啊

    0

  10. 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time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053289, encodeId=7bb61053289df, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee641592989, createdName=guoguolijuan, createdTime=Mon Sep 20 16:43:39 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 guoguolijuan

    学习了!

    0

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从NAFLD到MAFLD的变化对其与糖尿病、CKD和CVD之间的关联没有太大影响。采用MAFLD定义进一步确定了代谢性脂肪肝合并过度饮酒和HBV感染的患者,与非脂肪肝患者相比,发生糖尿病的风险增加。

静脉血糖1.1,末梢血糖5.1,这样的危急值你敢报吗?

血糖(GLU),顾名思义就是血液中的葡萄糖,正常人空腹血糖参考值为3.9~6.1mmol/L。血糖是人类能量的重要来源,人体需要补充适量的葡萄糖来提供能量,为各种组织、脏器的正常运作提供动力。

Diabetologia:少坐可以改善绝经后女性的代谢健康

在当今社会,大多数人的久坐行为占主导地位,并与患2型糖尿病的风险有关。运动是有效预防和治疗2型糖尿病的基石,但在欧洲和美国的成年人中,维持积极的生活方式并定期进行中等到高强度的体育活动的依从性很低。

Nat Commun:小檗碱治疗非酒精性脂肪性肝炎和2型糖尿病具有良好的耐受性

最近,研究人员报告了一项前瞻性、随机、双盲、安慰剂对照的HTD1801试验(小檗碱熊去氧胆酸,小檗碱和熊去氧胆酸的离子盐),该试验在100名患有脂肪肝和糖尿病的患者中进行(NCT03656744)。

50万人数据:预防心肌代谢性疾病只能看DASH和地中海饮食?中国饮食模式也能!

50万中国成年人的饮食模式与心脏代谢疾病:一项10年队列研究!

GUT:2型糖尿病的替代治疗:药物治疗还是内窥镜十二指肠粘膜重塑术? 

“代谢内镜领域 "是一个很有前途的新研究领域,它可能改变2型糖尿病的管理,并可能对消化科医生的内镜检查实践产生重大影响。