Lancet Oncol:派姆单抗联合疗法一线治疗HER2阳性转移性食管胃癌

2020-05-25 MedSci原创 MedSci原创

派姆单抗、曲妥珠单抗联合化疗可有效延长HER2阳性转移性食管胃癌患者无进展生存期

在一线化疗中加入曲妥珠单抗可提高HER2阳性转移性胃癌患者的整体生存率。 近日研究人员评估了派姆单抗、曲妥珠单抗和联合一线化疗在HER2阳性转移性食管胃(胃、食管或胃食管交界处)癌症中的疗效。
 
本次研究为II期试验, 18岁或18岁以上HER2阳性转移性食管胃癌患者参与,首先200mg派姆单抗以及8 mg/kg曲妥珠单抗诱导治疗。随后,患者在第1天接受130 mg/m 2的奥沙利铂或80 mg/m 2的顺铂治疗,每天两次口服卡培他滨850 mg/m 2,为期2周,间隔1周后,在每个3周的第1天,静脉注射200mg的派姆单抗和6 mg/kg的曲妥珠单抗。研究的主要终点是6个月无进展生存。
 
37名患者参与研究,幸存者中位随访时间为13.0个月,达到主要终点。37名患者中26名(70%)在6个月时无进展。最常见的任何级别治疗相关不良事件是神经病变(97%)。最常见的3级或4级不良事件是淋巴细胞减少(7例[19%]为3级,2例[5%]为4级)、3级电解质减少(6例[16%]患者)和3级贫血(4例[11%]患者)。两名患者出现严重不良事件(均为3级肾炎导致治疗中止)。4名患者因免疫相关的不良反应而停止使用派姆单抗。没有与治疗相关的死亡。
 
派姆单抗、曲妥珠单抗联合化疗可有效延长HER2阳性转移性食管胃癌患者无进展生存期。
 
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    2021-01-14 howi
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386627, encodeId=3593138662ec1, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Wed May 27 10:19:01 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437548, encodeId=c637143e54821, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 27 10:19:01 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600541, encodeId=94bc6005418d, content=又是一个新方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue May 26 05:32:38 CST 2020, time=2020-05-26, status=1, ipAttribution=)]
    2020-06-07 lovetcm

    #HER-2阳性#阳性率有多高?

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 27 10:19:01 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600541, encodeId=94bc6005418d, content=又是一个新方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue May 26 05:32:38 CST 2020, time=2020-05-26, status=1, ipAttribution=)]
    2020-08-22 minlingfeng
  6. 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  7. 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  9. 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    2020-05-27 zhouqu_8
  10. 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    2020-05-26 njwbhuang

    又是一个新方法

    0

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Int J Cancer:研究揭示EphA2-YAP通路驱动胃癌的生长和治疗耐药性的发生

Yes相关蛋白(YAP)是一种转录辅助激活剂,能促进细胞增殖、干细胞维持和组织平衡。YAP的活性主要是通过抑制性磷酸化的丝氨酸/苏氨酸激酶的Hippo通路来调节。

来自25个国家的研究:高咖啡摄入量竟会降低胃癌风险

导言:咖啡是世界上第二流行的饮料之一,它具有抗氧化和抗肿瘤特性。

Cancer:研究:过量吃辣椒,真能增加胃癌风险!

对于胃不好的人,医生往往建议要少吃“生冷酸辣”;

Science Advances:基因突变和饮酒的结合增加了东亚人患胃癌的风险

胃癌(GC)是一种十分常见的消化道肿瘤,由于胃癌起病比较隐匿,症状不典型,多数没有症状,或者是只有胃部不适、食欲不振、胃痛等症状,很容易被人们误认为是胃炎、胃溃疡等疾病,很难引起重视

Preprint:来自25个国家的研究:高咖啡摄入量竟会降低胃癌风险

导言:咖啡是世界上第二流行的饮料之一,它具有抗氧化和抗肿瘤特性。而胃癌是史上第五常见的肿瘤,同时也是导致死亡数第二高的肿瘤。关于咖啡摄入与胃癌发生的关系,已有相关学者进行研究,表明咖啡摄入量与胃癌发生