Med Sci Sports Exerc:运动训练可调节肠道微生物群特征,改善内毒素血症

2020-08-01 MedSci原创 MedSci原创

肥胖症和胰岛素抵抗时,肠道代谢和微生物区系受损。此外,紊乱的肠道微生物群可通过释放内毒素特别是脂多糖来促进全身性低度炎症和胰岛素抵抗。我们之前已经表明,运动训练可以改善健康男性的肠道代谢。为了了解肠道

肥胖症和胰岛素抵抗时,肠道代谢和微生物区系受损。此外,紊乱的肠道微生物群可通过释放内毒素特别是脂多糖来促进全身性低度炎症和胰岛素抵抗。我们之前已经表明,运动训练可以改善健康男性的肠道代谢。为了了解肠道代谢的变化是否与肠道微生物群及其炎症标志物的释放相互作用,我们研究了短跑间歇(SIT)和中等强度连续训练(MICT)对胰岛素抵抗受试者肠道代谢和微生物群的影响。

 

研究纳入了26名久坐的受试者(糖尿病前期,n = 9;2型糖尿病,n = 17;年龄,49[SD,4]岁;体重指数,30.5[SD,3]),将其随机分为SIT或MICT。使用正电子发射断层扫描测量肠道胰岛素刺激的葡萄糖摄取(GU)和循环中的脂肪酸摄取(FAU)。通过16S rRNA基因测序和血清炎症标志物,用多重检测和酶联免疫分析试剂盒分析肠道微生物群组成。

 

结果显示,V˙O2peak仅在SIT后有所改善(P=0.01)。两种训练模式均可降低系统性和肠道炎症标志物(肿瘤坏死因子-α、脂多糖结合蛋白)的水平(时间P<0.05)。通过增加门生拟杆菌门类(时间P = 0.03)和降低菌毛/拟杆菌比值(时间P = 0.04),训练可改变微生物群谱。此外,梭状芽胞杆菌属(时间P = 0.04)和蓝藻(时间P = 0.051)均有所降低。只有MICT降低了空肠FAU(P = 0.02)。训练对肠道GU没有显著影响。结肠GU与拟杆菌属呈正相关,与门扇菌属,门扇菌/拟杆菌比和蓝藻属成反比。

 

综上所述,该研究结果表明,肠道底物吸收与肠道微生物群组成和全身胰岛素敏感性有关。运动训练可改善肠道微生物群的组成,降低内毒素血症。

 

原始出处:

 

Kumail K MotianiM Carmen Collado, et al., Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112.

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