Clinica Chimica Acta:血清碱性磷酸酶水平与代谢综合征呈正相关?

2020-03-01 MedSci MedSci原创

血清碱性磷酸酶(ALP)是一种肝胆或骨骼疾病的有用标志物,近年来已成为慢性低度炎症和心脏代谢疾病的生物标志物。本研究旨在探讨健康成年人血清ALP水平与代谢综合征(MetS)的关系。 这项横断面研究使用2008年至2011年韩国国民健康与营养检查调查的数据,调查了19至75岁的7101名男性和8873名女性的血清ALP水平与MetS的关系。 通过对血清ALP四分位数(Q1:≤190U / L

血清碱性磷酸酶(ALP)是一种肝胆或骨骼疾病的有用标志物,近年来已成为慢性低度炎症和心脏代谢疾病的生物标志物。本研究旨在探讨健康成年人血清ALP水平与代谢综合征(MetS)的关系。

这项横断面研究使用2008年至2011年韩国国民健康与营养检查调查的数据,调查了1975岁的7101名男性和8873名女性的血清ALP水平与MetS的关系。 通过对血清ALP四分位数(Q1≤190U / L; Q2191-224 U / L; Q3225-263)进行多元logistic回归分析来计算MetS的优势比(OR)和95%置信区间(CI)。 U / L;和Q4:男性≥264 U / LQ1≤163U / L Q2164-201 U / L Q3202-251 U / L Q4:≥252U / L 女性)。。

研究结果显示大多数心脏代谢变量、HOMA-IR和白细胞计数的平均值随血清ALP四分位数的增加而逐渐升高。根据血清ALP四分位数,MetS患病率显著增加。经年龄、吸烟、饮酒、定期锻炼、家庭收入、教育水平、职业、ASTALTGGT水平校正后,与最低四分位的个体相比,最高四分位的metOR (95% CI)为男性1.32(1.05-1.64),女性1.99(1.42-3.81)

研究表明,血清ALP水平与男女MetS呈正相关且独立。

原始出处:

Ji-Hye Kim,Hye Sun Lee,Serum alkaline phosphatase level is positively associated with metabolic syndrome: A nationwide population-based study

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    2020-10-11 zutt
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    2021-01-21 windight
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