SCI REP:肝脏脂肪、肝酶、碱性磷酸酶与2型糖尿病发病风险分析!

2017-07-05 xing.T MedSci原创

该研究结果表明非酒精性脂肪性肝病、ALT、AST、GGT、ALP是男性和女性发生糖尿病的独立预测因素。

既往的研究已经报道了丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)与2型糖尿病的发生之间的相关性,但是这些结果并不一致。

近日,Scientific reports 杂志上发表了一篇研究文章,研究人员的目的是将非酒精性脂肪肝(NAFLD)纳入后解决这一问题的争议。该研究的研究人群包括了132377名非糖尿病患者(64875名男性和67502名女性),年龄在35岁至79岁之间,这些参与者在1996年至2014年期间进行过两次或两次以上的健康检查。

研究人员共发现了6555例糖尿病患者(男性有3734例,女性有2821例),平均随访5.8年。研究人员采用Cox回归计算了发生糖尿病的风险比(HR),对经典混杂因素进行调整后。研究人员发现糖尿病发生的风险性与NAFLD显著相关(男性受试者的HR为2.08,女性受试者的HR为2.65)。升高的ALT、AST、GGT和ALP也与糖尿病风险增加显著相关,其糖尿病发生的HR,在男性中分别为1.27、1.23、1.58和1.37,在女性中分别为1.56、1.18、1.48和1.44。

该研究结果表明非酒精性脂肪性肝病、ALT、AST、GGT、ALP是男性和女性发生糖尿病的独立预测因素。

原始出处:

Sean Chun-Chang Chen,et al. Liver Fat, Hepatic Enzymes, Alkaline Phosphatase and the Risk of Incident Type 2 Diabetes: A Prospective Study of 132,377 Adults.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04631-7#Sec5

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    2017-07-13 李东泽

    很好,不错,以后会多学习

    0

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    2017-07-06 大爰

    学习并分享好文章!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=221706, encodeId=5f7b221e0646, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Jul 13 08:12:07 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584010, encodeId=1f5a158401081, content=<a href='/topic/show?id=e9d1e371386' target=_blank style='color:#2F92EE;'>#碱性磷酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73713, encryptionId=e9d1e371386, topicName=碱性磷酸酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=335616999328, createdName=12498e8em77暂无昵称, createdTime=Fri Jul 07 09:34:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596024, encodeId=f7a1159602496, content=<a href='/topic/show?id=7b24e386455' target=_blank style='color:#2F92EE;'>#磷酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73864, encryptionId=7b24e386455, topicName=磷酸酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584e18318123, createdName=andy2093, createdTime=Fri Jul 07 09:34:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603630, encodeId=2ada160363073, content=<a href='/topic/show?id=0018814e070' target=_blank style='color:#2F92EE;'>#肝脏脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81470, encryptionId=0018814e070, topicName=肝脏脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dee19073592, createdName=fengting9, createdTime=Fri Jul 07 09:34:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218984, encodeId=ae6821898468, content=学习并分享好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jul 06 05:46:07 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218922, encodeId=c5652189224e, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Jul 05 20:31:07 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 changjiu

    学习了,谢谢

    0

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JAHA:肝脏脂肪与房颤发病率和患病率之间有啥关系?

在社区为基础的纵向队列研究中,研究人员发现通过计算机断层扫描得到的肝脏脂肪与随访12年后房颤的患病率和发病率之间没有显著的相关性。