Osteoporos Int:饮酒是否增加髋部骨折风险 因年龄和性别而异

2018-12-24 王淳 环球医学

2018年7月,挪威学者发表在《Osteoporos Int》的NOREPOS研究表明,挪威队列中,酒精摄入和髋部骨折风险之间的相关性随着年龄和性别的不同而具有差异。

2018年7月,挪威学者发表在《Osteoporos Int》的NOREPOS研究表明,挪威队列中,酒精摄入和髋部骨折风险之间的相关性随着年龄和性别的不同而具有差异。

介绍:本研究旨在基于人群的挪威队列(1994~2003)中,检测不同性别和年龄的人群,酒精摄入与髋部骨折风险的相关性。

方法:研究者测量了≥30岁的70568名男性和71357名女性的社会人口统计学、生活方式、自我报告的健康状况、体重和身高信息。1994~2013年,从医院的电子病历注册中获取随后髋部骨折的信息。对酒精摄入频率进行分类:从不/很少、中等(≤2~3次/周)、频繁(≥4次/周),酒精摄入量分类为0、1~6、7~13、14~27、28+(单位为杯/周)。也检测了酒精类型(葡萄酒vs啤酒/烈酒)。Cox比例风险回归用于评估风险比(HR),并根据性别和基线年龄<60岁和≥60岁进行分层。

结果:中位15年的随访期,1558名男性和2511名女性髋部骨折。使用中等饮酒者作为参考,频繁饮酒的<60岁男性的髋部骨折的多变量调整HR为1.73(CI,1.02~2.96),与摄入1~6杯/周相比,摄入14+杯/周者的风险高2.5倍多。在其他年龄和性别组中,摄入最高水平酒精者中,风险未统计学显着性增加。与中度或频繁饮酒的女性相比,从不/很少饮酒的女性具有最高的骨折风险。在女性中,与其他类型的酒精相比,葡萄酒与较低的骨折风险相关。

结论:具有最高频率和最高酒精摄入量的<60岁的男性和非饮酒女性,髋部骨折风险最高。

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    2018-12-30 wxl882001

    了解一下

    0

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    2018-12-26 lsndxfj
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    2018-12-26 liuquan
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    2018-12-24 医者仁心5538

    学习了

    0

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