JAHA:心电图对急性药物过量的诊断效能如何?

2017-02-14 xing.T MedSci原创

该研究证实了早期心电图检查对于急诊急性药物过量患者心血管预后和医疗清除评估是必要的。此外,这项研究证实了先前获得的药物过量患者ACVE危险分层的入院高风险心电图特征。

以肯定的是急诊一些急性药物过量的患者会发生不良心血管事件(ACVE),然而这类患者ACVE的预测较为困难。用心电图(ECG)对异构药物过量的患者进行预后预测的效能还有待证实。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。该研究旨在验证药物过量患者ACVE相关的初始心电图特点。

研究人员在2个城市大学医院进行了一项为期5年的前瞻性验证队列研究,以评估成年急诊急性药物过量患者,这些患者在急诊科就诊时进行了ECG检查。该研究的排除标准为诊断变化、过敏、慢性药物毒性和结局数据丢失。ACVE被定义为以下任何一种情况:循环休克、心肌损伤、心室节律紊乱或心脏骤停。被隐瞒分组的心脏病学家解释了先前获得的ACVE心电图预测指标(异位起博、QT间期延长、非窦性节律、缺血/梗死)、QT离散度和aVR导联明显R波。

研究人员发现589例患者符合纳入标准(48%为男性,平均年龄为42岁),有95例患者发生ACVE(39例休克、64例心肌损伤、26例心律失常、16例心脏骤停)。最常见的过量药物如下:苯二氮卓类药物、阿片类药物和对乙酰氨基酚。先前获得的标准可以很好的预测ACVE,其中校正的QT间期>500ms为最高风险的特征(比值比为11.2,可信区间为4.6-27)。

该研究证实了早期心电图检查对于急诊急性药物过量患者心血管预后和医疗清除评估是必要的。此外,这项研究证实了先前获得的药物过量患者ACVE危险分层的入院高风险心电图特征。

原始出处:

Alex F. Manini,et al. Validation of the Prognostic Utility of the Electrocardiogram for Acute Drug Overdose. JAHA.2017. https://doi.org/10.1161/JAHA.116.004320

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    2017-02-16 zhaohui6731
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    2017-02-15 1e10c84am36(暂无匿称)

    文章真心不错耶

    0

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    2017-02-15 cqykthl

    早期心电图检查对于急诊急性药物过量患者心血管预后和医疗清除评估是必要的

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2032319, encodeId=9e40203231908, content=<a href='/topic/show?id=e12f8e880fb' target=_blank style='color:#2F92EE;'>#药物过量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87880, encryptionId=e12f8e880fb, topicName=药物过量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Sun Jul 16 05:34:00 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267388, encodeId=e967126e388d2, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Feb 16 08:34:00 CST 2017, time=2017-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176231, encodeId=54be1e62315d, content=文章真心不错耶, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Feb 15 09:53:09 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176220, encodeId=a0b11e622069, content=早期心电图检查对于急诊急性药物过量患者心血管预后和医疗清除评估是必要的, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Feb 15 08:39:34 CST 2017, time=2017-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176209, encodeId=5ef91e6209e6, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed Feb 15 08:19:15 CST 2017, time=2017-02-15, status=1, ipAttribution=)]
    2017-02-15 laoli

    谢谢分享!

    0

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大多数猝死由于恶性心律失常引起。患者猝死前,其心电图一般会表现出异常改变。那么哪些心电图的异常改变标志着猝死的发生?且听界妹一一道来:R-on-T心电图R-on-T心电图:提前出现的室性早搏,发生在前一心动周期的T波上(波峰、前支、后支)。前一心动周期的T波意味着心室处于易反复激动的易损期,故落在T波上的室性早搏刺激,易导致室速、室颤的发生。如上图,室早落在前一心动周期的T波上,第二个室早诱发了短

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猝死恐慌曾笼罩东南亚上世纪数十年间,一个可怕的谜团如幽灵般游荡在东南亚各国,从菲律宾到泰国,从缅甸到老挝,众多平素健康的青壮年在夜间不明原因地猝死,而且绝大多数为男性。统计数据表明,青壮年发生这种神秘死亡的人数位列交通事故死亡人数之后,高居第二位,且猝死还呈家族聚集性,从而造成了更大程度的恐慌。为何死神如此无情又频频光顾,无人能够回答,医学也无法给予合理的解释。  当科学被阴霾

小小心电图 图里藏乾坤

本例患者为青中年男性,住院期间治愈了感染性疾病,但却“治出了”致命的尖端扭转型室速和室颤。虽说患者本身存在心脏电生理的问题,但也难免有“雪上加霜”的嫌疑。