Prostate Cancer P D:术前PI-RADS V2评分能够提高临床列线图的准确性

2019-08-20 AlexYang MedSci原创

淋巴结浸润(LNI)是前列腺癌(PCa)的一种强烈的不良预后因素。最近, 有研究人员评估了前列腺成像报告和数据系统V2(PI-RADS V2)评分在评估LN转移中的作用。同时,研究人员还调查了当于临床列线图组合运用来对PCa患者的LNI进行预测时,PI-RADS V2评分的其他用途。研究人员回顾性的鉴定了308名经历了多参数核磁共振成像(mpMRI)和RP且进行了盆腔淋巴结清扫(PLND)的患者,

淋巴结浸润(LNI)是前列腺癌(PCa)的一种强烈的不良预后因素。最近, 有研究人员评估了前列腺成像报告和数据系统V2(PI-RADS V2)评分在评估LN转移中的作用。同时,研究人员还调查了当于临床列线图组合运用来对PCa患者的LNI进行预测时,PI-RADS V2评分的其他用途。

研究人员回顾性的鉴定了308名经历了多参数核磁共振成像(mpMRI)和RP且进行了盆腔淋巴结清扫(PLND)的患者,并评估了临床病理参数和PI-RADS V2得分。研究发现,20(6.5%)名患者具有LNI。单变量分析中,所偶的临床病理特性和PI-RADS V2得分与LNI均显著相关(p<0.04)。然而,多变量分析阐释了只有PI-RADS V2得分和阳性核心比例独立相关(p<0.006)。PI-RADS V2评分是最为准确的预测因子(AUC,80.2%)。另外,PI-RADS V2评分的阈值为5,具有高度的敏感性(18/20,90%)和阴性预测值(203/205, 99.0%)。当PI-RADS V2得分与Briganti和MSKCC列线图组合使用时,AUC值从分别从75.1%和79.2%增加到86.3%和87.9%(p<0.001)。DCA同时也阐释了上述2个列线图与PI-RADS V2评分组合使用时能够改善LNI的临床风险预测。

最后,研究人员指出,PI-RADS V2评分小于5的前列腺癌患者与非常低的LNI风险相关。根治性前列腺切除术时,术前PI-RADS V2评分能够帮助提高预测盆腔LN转移的临床列线图的准确性。

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    2020-02-25 江川靖瑶
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    2019-08-22 医者仁心
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    2019-08-22 sunylz

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前列腺癌(PC)起初是依赖雄激素受体(AR)信号来维持生存和生长的。抑制AR活性的治疗方法是晚期疾病的主要干预手段。然而,超生理雄激素(SPA)浓度能够产生矛盾的结果,即导致PC生长的抑制。最近,有研究人员探究了SPA抑制PC的机制,并确定了是否分子环境与抗肿瘤活性有关。研究发现,SPA能够产生一种AR调控的、剂量依赖的DNA双链断裂(DSBs),GO/G1细胞周期阻滞和细胞衰老。SPA能够抑制参

Sci Rep:标准临床3T前列腺MRI在盆腔淋巴结分期中的准确度研究

最近,有研究人员在前列腺癌(PCa)中评估了前列腺3TMRI在盆腔淋巴结(LN)分期中的表现情况,并将68镓-前列腺特异性膜抗原PET-CT(68Ga-PSMAPET-CT)作为LN检测的参考标准。研究共包括了130名PCa患者,他们在180内经历了非对比度增强多参数前列腺3TMRI和68Ga-PSMA-PET-CT。研究发现,由68Ga-PSMAPET-CT检测到的187个LN转移(n=43名患

Cell Death Dis:IFITM3能够促进前列腺癌细胞的骨转移

晚期阶段前列腺癌(PCa)总是能够诊断出骨转移,并且治疗方法有限。转化生长因子β(TGF-β)能够诱导上皮-间质转化(EMT),并且TGF-β在骨基质中的丰度是重要的生长因素之一,并且有利于骨转移。据报道,TGF-β是骨转移的关键调控因子,但是潜在的机制仍旧不清楚。最近,有研究人员发现干扰素诱导的跨膜蛋白3(IFITM3)通过与Smad4结合激活TGF-β-Smads信号途径,在恶性肿瘤细胞增殖、

Eur Urol Oncol:根治性前列腺癌切除术后抑郁风险研究

前列腺癌患者抑郁的发展依赖于多个疾病相关和患者相关的因素。最近,有研究人员调查了根治性前列腺癌切除术后抑郁的风险情况,并且主要关注手术和随后的挽救性放射疗法或者雄激素阻断疗法治疗的影响。在跟踪调查的18年中,研究发现抑郁的累积患病率在那些经历手术的男性中要比无癌症男性高,尤其是在那些经历了雄激素阻断治疗的男性中。在调整了年龄、手术年数、收入和同居情况后,研究人员发现,与没有随后的治疗相比,随后雄激