Clin & Trans Gastroenterology 有和没有慢性便秘患者之间排便欲望的差异的分析

2020-09-13 MedSci原创 MedSci原创

慢性便秘(CC)是一种常见的功能性胃肠道疾病,在全球范围内患病率高达2%–27%。男性和女性的CC患病率均随着年龄的增长而增加。

        慢性便秘(CC)是一种常见的功能性胃肠道疾病,在全球范围内患病率高达2%–27%。男性和女性的CC患病率均随着年龄的增长而增加,患有CC的个体在身心方面通常都会表现出明显降低的生活质量。其中,排便欲望(DD)下降的非常明显,DD是直肠壁扩张时产生的感觉,是正常排便的重要组成部分。便秘患者经常报告排便欲望的丢失(LODD)可能是由于直肠感觉受损所致。因此,这项研究的目的是评估(i)在患有和没有CC的个体中LODD的患病率,以及(ii)在接受CC及其相关治疗的患有CC的个体中LODD的患病率治疗满意。

       

 

        主要研究方法是在2019年2月27日至2019年3月8日间研究人员进行了一次互联网问卷调查,对包括20岁及80岁以上的患者进行了关于便秘情况和排便情况的调查,接受便秘治疗的参与者在开始治疗前被要求回忆他们的肠道症状。最后使用逻辑回归分析数据。P小于0.05值或更小被认为是统计学差异。

 

         研究结果显示:本项研究总共包括20986名参与者。在这些参与者中,有2587名参与者(1,036名男性和1,551名女性,平均年龄51.0岁)符合罗马IV的便秘标准,但不符合IBS的标准,因此被纳入CC组。非CC对照组随机分配了相同数量的年龄/性别匹配参与者,CC组的LODD发生率显着高于非CC组(57.4%vs 8.3%,P <0.001;[OR] 14.84 [95%置信区间12.65-17.42]),CC个体的LODD发生率高于所有年龄组的非CC对照组患者。CC组共有443名参与者因便秘接受治疗,并被纳入CC-P组。CC-P组的443名患者中,有285名(64.3%)在开始治疗前患有LODD,治疗后的LODD率为27.1%(120/443),CC-P患者中只有48.3%表示对治疗感到满意或有些满意。超过一半的人对其目前的治疗不满意。

 

        因此,最后研究人员说道:与非CC对照相比,LODD在CC患者中更为常见,并且治疗降低了CC患者的LODD发生率。但是,持续性LODD患者的满意度很低,因此提高LODD对于治疗满意度至关重要。

 

原始出处:

Ohkubo, Hidenori. Et al. Difference in Defecation Desire Between Patients With and Without Chronic Constipation: A Large-Scale Internet Survey. Clinical and Translational Gastroenterology.2020.

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    2021-01-19 许安
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    2021-07-17 kkunny
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encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 12 19:20:48 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886143, encodeId=1166886143a5, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200913/4079e88c046148308a7d940034ef5b7b/55c1bffa91f7423095a637db7895a259.jpg, createdBy=8ab65414576, createdName=ms9000001942336842, createdTime=Thu Sep 17 19:02:58 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505075, encodeId=defd15050e57d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Sep 15 01:20:48 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884989, encodeId=a92f884989a2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Sun Sep 13 18:08:31 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884918, encodeId=dcd18849187a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=e2695417837, createdName=ms9000001074629481, createdTime=Sun Sep 13 10:52:04 CST 2020, time=2020-09-13, status=1, ipAttribution=)]
    2021-01-15 bsmagic9140
  5. 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encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 12 19:20:48 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886143, encodeId=1166886143a5, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200913/4079e88c046148308a7d940034ef5b7b/55c1bffa91f7423095a637db7895a259.jpg, createdBy=8ab65414576, createdName=ms9000001942336842, createdTime=Thu Sep 17 19:02:58 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505075, encodeId=defd15050e57d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Sep 15 01:20:48 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884989, encodeId=a92f884989a2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb682417917, createdName=1238d654m87暂无昵称, createdTime=Sun Sep 13 18:08:31 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884918, encodeId=dcd18849187a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=e2695417837, createdName=ms9000001074629481, createdTime=Sun Sep 13 10:52:04 CST 2020, time=2020-09-13, status=1, ipAttribution=)]
    2020-10-24 Dr.R Z

    科普哈

    0

  6. 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encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 12 19:20:48 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886143, encodeId=1166886143a5, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200913/4079e88c046148308a7d940034ef5b7b/55c1bffa91f7423095a637db7895a259.jpg, createdBy=8ab65414576, createdName=ms9000001942336842, createdTime=Thu Sep 17 19:02:58 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505075, encodeId=defd15050e57d, content=<a 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  7. 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encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 12 19:20:48 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886143, encodeId=1166886143a5, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200913/4079e88c046148308a7d940034ef5b7b/55c1bffa91f7423095a637db7895a259.jpg, createdBy=8ab65414576, createdName=ms9000001942336842, createdTime=Thu Sep 17 19:02:58 CST 2020, time=2020-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505075, encodeId=defd15050e57d, content=<a 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    2020-09-17 ms9000001942336842

    0

  8. 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  9. 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    2020-09-13 1238d654m87暂无昵称

    学习

    0

  10. 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    2020-09-13 ms9000001074629481

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