Allergy:食物依赖的NSAID诱导的超敏反应(FDNIH):揭示其临床特征和风险因素

2020-12-22 AlexYang MedSci原创

在高达70-80%的疑似非甾体类抗炎药过敏症(NSAIDH)患者中,当使用相关药物进行过敏挑战试验时结果为阴性。另一方面,当过敏性休克是临床表现时,可能存在NSAIDH的过度诊断。最近,有研究人员推测

在高达70-80%的疑似非甾体类抗炎药过敏症(NSAIDH)患者中,当使用相关药物进行过敏挑战试验时结果为阴性。另一方面,当过敏性休克是临床表现时,可能存在NSAIDH的过度诊断。最近,有研究人员推测,在食物依赖性NSAID诱导的过敏症(FDNIH)患者中,一些NSAID挑战试验阴性和NSAIDH的过度诊断是会发生的。

研究包括了328名疑似疑似急性NSAIDH的患者。结果表明,199名患者(60%)诊断为NSAIDH,52名(16%)诊断为FDNIH。44名患者(84.6%)中涉及Pru p 3;6名患者(11%)中涉及Tri a 19。FDNIH受试者年龄较小(P<0.001),鼻炎发病率较高(P<0.001),既往有食物过敏(P<0.001),同时对花粉(P<0.001)和食物(P<0.001)过敏的比例较高。另外,仅使用四个变量(Pru p 3和Tri a 19致敏、过敏性休克和任何不同于吡唑酮类的非甾体抗炎药)时,95.3%的病例就能够正确分类,且灵敏度为92%,特异性为96%。

多变量分析

最后,研究人员指出,FDNIH的评估应纳入NSAIDH的诊断工作中

原始出处:

Jaime Sánchez-López, Giovanna Araujo, Victoria Cardona et al. Food-dependent NSAID-induced hypersensitivity reactions (FDNIH): unraveling the clinical features and risk factors. Allergy. Dec 2020

 

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    2021-04-01 d830372
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    2021-07-04 wjywjy
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1842961, encodeId=7d8718429619e, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Mon Jan 18 10:13:09 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793601, encodeId=b8c51e9360186, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a244, createdName=d830372, createdTime=Thu Apr 01 04:13:09 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033888, encodeId=4ef520338885f, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Sun Jul 04 03:13:09 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984347, encodeId=73a6198434e7c, content=<a href='/topic/show?id=fef19285519' target=_blank style='color:#2F92EE;'>#超敏反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92855, encryptionId=fef19285519, topicName=超敏反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Mon Apr 12 13:13:09 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329446, encodeId=ea23132944605, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413654, encodeId=b0eb141365461, content=<a href='/topic/show?id=9209130645d' target=_blank style='color:#2F92EE;'>#NSAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13064, encryptionId=9209130645d, topicName=NSAID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80342986042, createdName=amyloid, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416902, encodeId=23481416902bd, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536938, encodeId=43e11536938da, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2020-12-24 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=1842961, encodeId=7d8718429619e, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Mon Jan 18 10:13:09 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793601, encodeId=b8c51e9360186, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a244, createdName=d830372, createdTime=Thu Apr 01 04:13:09 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033888, encodeId=4ef520338885f, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Sun Jul 04 03:13:09 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984347, encodeId=73a6198434e7c, content=<a href='/topic/show?id=fef19285519' target=_blank style='color:#2F92EE;'>#超敏反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92855, encryptionId=fef19285519, topicName=超敏反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6732482, createdName=w984445tii, createdTime=Mon Apr 12 13:13:09 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329446, encodeId=ea23132944605, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413654, encodeId=b0eb141365461, content=<a href='/topic/show?id=9209130645d' target=_blank style='color:#2F92EE;'>#NSAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13064, encryptionId=9209130645d, topicName=NSAID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80342986042, createdName=amyloid, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416902, encodeId=23481416902bd, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536938, encodeId=43e11536938da, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Thu Dec 24 14:13:09 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2020-12-24 amyloid
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    2020-12-24 yhy100201
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    2020-12-24 宋威

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