Am Heart J:钾的输注增加了近期发作的房颤转变为窦性心律的可能性

2020-08-12 MedSci原创 MedSci原创

近期发作的房颤(ROAF)或房扑的最佳抗心律失常管理存在争议,临床治疗策略也存在相当大的差异。目前尚不清楚输钾是否有可能将ROAF或房扑转化为窦性心律(SR)。因此,本研究旨在探究ROAF或心房扑动且

近期发作的房颤(ROAF)或房扑的最佳抗心律失常管理存在争议,临床治疗策略也存在相当大的差异。目前尚不清楚输钾是否有可能将ROAF或房扑转化为窦性心律(SR)。因此,本研究旨在探究ROAF或心房扑动且血浆钾水平≤4.0 mmol/L的患者,如果血浆钾水平向参考范围上限(4.1-5.0 mmol/L)增加,是否会增加转为SR的可能性。

 

在一项安慰剂对照的单盲试验中,2013年4月至2017年11月期间出现ROAF或房扑且血浆钾≤4.0 mmol/L的患者随机接受氯化钾(KCl)(n = 60)或安慰剂(n = 53)输注。KCl组的患者接受三种不同速率的输液:9.4mmol/h(n = 11)、12mmol/h(n = 19)或15mmol/h(n = 30)。

 

结果显示,KCl组和安慰剂之间转换为SR的数量没有统计学差异[logrank检验,P = .29;危险比(HR)1.20(CI 0.72-1.98)]。然而,与安慰剂组和血浆钾变化低于中位数的KCl患者[logrank P < .001;HR 4.41(CI 2.07-9.40)]相比,实现高于中位数的每小时血浆钾增加的KCl输注患者(>0.047 mmol/h),表现出显著更高的转换率[logrank P = .002;HR 2.40(CI 1.36-4.21)]。由于输液部位的疼痛,10名患者(17%)提前终止输液。

 

总之,该研究结果表明,虽然血浆钾水平的升高并不能显着提高钾水平在正常范围以下的患者的ROAF或房扑向SR的转化,但该研究结果表明,当患者耐受并可实现快速增加钾浓度时,这种治疗可能是有效的。

 

原始出处:

 

Kiarash TazminiMai S Aa Fraz, et al., Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial. Am Heart J. 2020 Mar;221:114-124. doi: 10.1016/j.ahj.2019.12.014. 

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    2020-08-13 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=1357587, encodeId=a585135e587a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 13 15:38:19 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476266, encodeId=f86614e62667e, content=<a href='/topic/show?id=1abce558582' target=_blank style='color:#2F92EE;'>#窦性心律#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75585, encryptionId=1abce558582, topicName=窦性心律)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e147265575, createdName=paperyu, createdTime=Thu Aug 13 15:38:19 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563355, encodeId=571c156335566, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Aug 13 15:38:19 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807617, encodeId=085680e61789, content=可是具体得输多少呢?高钾的危害更大呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Aug 12 08:57:57 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031292, encodeId=f8ee1031292e5, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Aug 12 03:38:19 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807578, encodeId=c9dc80e5780f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Aug 12 00:41:28 CST 2020, time=2020-08-12, status=1, ipAttribution=)]
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    2020-08-13 slcumt
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    2020-08-12 Psycho.Dr Du

    可是具体得输多少呢?高钾的危害更大呀

    0

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    2020-08-12 心介

    房颤,临床上碰到很多哦

    0

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    2020-08-12 zb1235672

    学习

    0

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