Clin Nutrition: 25(OH)D的生物利用度与弥漫性大B细胞淋巴瘤患者的临床结局相关

2021-01-10 MedSci原创 MedSci原创

我们已经知道,维生素D功能不足与多种癌症类型的临床结局较差有关。然而,其在弥漫性大B细胞淋巴瘤(DLBCL)患者中的作用仍不清楚。

      我们已经知道,维生素D功能不足与多种癌症类型的临床结局较差有关。然而,其在弥漫性大B细胞淋巴瘤(DLBCL)患者中的作用仍不清楚。在本项研究中,研究人员旨在确定DLBCL患者中循环总25(OH)D和生物利用度25(OH)D水平在判断疾病预后中的作用。

 

 

       研究人员总共招募了332名新诊断的DLBCL患者。对患者诊断时的血浆总25(OH)D和生物利用度25(OH)D水平进行了检测,并评估它们与临床特征和患者预后的关系。还评估了DLBCL患者对化疗(R-CHOP)治疗反应的临床特征和25(OH)D水平的截断值。

 

 

      在本项研究中的患者中,有92.8%的患者维生素D状态不足(<30 ng / mL)。血浆生物利用度较高的25(OH)D患者具有更好的疾病无进展生存期(HR = 0.72,95%CI = 0.38–1.35,P = 0.301)和总体生存率(HR = 0.89,95%CI = 0.39-2.02,P = 0.777)。同时,DLBCL患者较高的血浆总25(OH)D水平与更好的疾病无进展生存期(PFS)显着相关,而与总体生存率(OS)无关。此外,总或生物利用度较高的25(OH)D水平较高的DLBCL患者对R–CHOP方案治疗更为敏感。

 

      因此,通过本项研究证实25(OH)D的生物利用度水平可作为DLBCL患者的一种新的预后生物标志物。

 

 

原始出处:

Peizhan Chen. Et al. Bioavailable 25(OH)D level is associated with clinical outcomes of patients with diffuse large B-cell lymphoma: An exploratory study. Clinical Nutrition.2021.

 

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世界上首次利用基因编辑技术在PD1位点实现定点整合的CART治疗,也是全球首例非病毒定点整合CART细胞治疗淋巴瘤的临床试验。

Nature:组蛋白H1缺失破坏染色质3D结构,驱动淋巴瘤发展 

研究人员还确立了H1作为一种真正的肿瘤抑制因子,并表明H1的突变主要通过三维基因组重组驱动恶性转化,从而导致表观遗传学重编程和发育沉默基因的去抑制。

ATG-010(selinexor)完成首例复发难治性外周T和NK/T细胞淋巴瘤患者给药

9月14日,德琪医药宣布口服选择性核输出抑制剂ATG-010(selinexor)用于治疗复发难治性外周T细胞淋巴瘤(PTCL)和NK/T细胞淋巴瘤(NKTL)患者的Ib期临床试验(代号:TOUCH)

第八届全国血液肿瘤学术大会,面临淋巴瘤造血干细胞移植应用困境,血液医生如何破局?

中国淋巴瘤患者5年生存率约30%,欧美则高达60-70%。在国内,北京肿瘤医院的数据显示5年生存率达到62%,接近欧美发达国家水平。

Blood:打破MALT1反馈机制或可使MALT1抑制剂的抗淋巴瘤疗效很大化

MALT1抑制剂依赖于组成性或异常信号通路,是治疗B细胞淋巴瘤的有效药物。然而,信号转导靶向治疗的一个潜在限制是反馈机制的发生,使肿瘤细胞能够逃脱此类药物的全部影响。