艾伯维的口服JAK抑制剂RINVOQ获得加拿大批准,用于治疗中度至重度活动性类风湿性关节炎

2020-01-08 不详 MedSci原创

艾伯维今天宣布,加拿大卫生部已批准RINVOQ(upadacitinib)用于治疗对甲氨蝶呤(MTX)反应或耐受不良的中度至重度活动性类风湿性关节炎成人患者。RINVOQ是一种15毫克,每日一次的口服Janus激酶(JAK)抑制剂,可用作单一疗法,或与MTX或其他非生物学疾病缓解性抗风湿药(DMARD)组合使用。

艾伯维今天宣布,加拿大卫生部已批准RINVOQ(upadacitinib)用于治疗对甲氨蝶呤(MTX)反应或耐受不良的中度至重度活动性类风湿性关节炎成人患者。RINVOQ是一种15毫克,每日一次的口服Janus激酶(JAK)抑制剂,可用作单一疗法,或与MTX或其他非生物学疾病缓解性抗风湿药(DMARD)组合使用。

该批准获得了关键的3期SELECT类风湿关节炎(RA)研究有效性和安全性数据的支持,这是RA中最大的注册3期计划之一,在5项研究1-5中评估了大约4400例患者。

多伦多大学医学教授Edward Keystone博士说:"尽管过去二十年来在类风湿关节炎的治疗方面取得了巨大进展,但仍有太多患者的症状无法缓解,并继续遭受疼痛、疲劳和晨起的关节僵硬。RINVOQ是治疗类风湿性关节炎领域最大的3期临床试验计划之一,该药物具有显着改善疾病迹象和症状的潜力。"

Western大学的Janet Pope博士提到:"类风湿关节炎影响100名加拿大人中的1名,并导致许多人致残。RINVOQ已被批准用于治疗中度至重度活动性类风湿关节炎,并为患有这种破坏性自身免疫性疾病的患者提供了希望。"

AbbVie加拿大副总裁兼总经理StéphaneLassignardie补充说:"近二十年来,AbbVie一直致力于为风湿病患者发现并提供创新的疗法。我们为能够为患有RA的加拿大人提供更多治疗选择而感到自豪,特别是通过为人们提供每日一次口服的缓释片剂。"

原始出处:

http://www.firstwordpharma.com/node/1691764?tsid=4#axzz6AP5R7iB8

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topicList=[TopicDto(id=22146, encryptionId=bf162214668, topicName=中度至重度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Thu Jul 23 23:22:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266085, encodeId=a56412660852e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Jan 10 04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312632, encodeId=449a131263282, content=<a href='/topic/show?id=1aa333006b4' target=_blank style='color:#2F92EE;'>#加拿大#</a>, beContent=null, 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04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350225, encodeId=8550135022547, content=<a href='/topic/show?id=bc1086e4652' target=_blank style='color:#2F92EE;'>#艾伯维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86746, encryptionId=bc1086e4652, topicName=艾伯维)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 10 04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483645, encodeId=4edf1483645d1, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Jan 10 04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852233, encodeId=c0ef185223358, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Sep 14 03:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=)]
  5. 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04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350225, encodeId=8550135022547, content=<a href='/topic/show?id=bc1086e4652' target=_blank style='color:#2F92EE;'>#艾伯维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86746, encryptionId=bc1086e4652, topicName=艾伯维)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 10 04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483645, encodeId=4edf1483645d1, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Fri Jan 10 04:22:00 CST 2020, time=2020-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852233, encodeId=c0ef185223358, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Sep 14 03:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=)]
    2020-01-10 lmm397
  6. 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  7. 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  8. 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    2020-09-14 jklm09

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