Lancet:四种降压治疗策略对心血管疾病风险的影响研究

2019-08-01 MedSci MedSci原创

10年心血管风险QRISK 2是最为有效的血压控制评估方法

目前,降压治疗主要以血压阈值为指导,近日英国研究人员考察了新的血压治疗的替代策略。

30-79岁,无心血管疾病的初级保健者参与研究,对四种不同的治疗策略进行了评估和比较:使用2011年英国国家健康和护理卓越研究所(NICE)指南、2019年NICE指南、血压阈值(≥140/90 mm HG)以及10年心血管风险(QRISK 2评分为≥10%)。对患者进行随访,直到心血管疾病的早期诊断、死亡或随访期结束(2016年3月31日)。

1222670名参与者,平均随访4.3年,其中271963名参与者符合2011NICE的治疗标准(22.2%),327429名参与者符合2019年NICE标准(26.8%),481859名参与者血压140/90 mm Hg及以上(39.4%),357840名参与者QRISK2评分10%(29.3%)。随访期间,32183名患者诊断心血管疾病(每1000随访年发病7.1例),每1000随访年中,符合2011NICE指南、2019年NICE指南、血压≥140/90 mm HG以及QRISK 2评分为≥10%患者的心血管事件分别为15.2例、14.9例、11.4例以及16.9例。放大到整个英国,以2011NICE指南、2019年NICE指南、血压≥140/90 mm HG以及QRISK 2评分为≥10%进行血压控制可分别减少233152例、270233例、301523例以及322921例心血管事件。

研究认为,10年心血管风险QRISK 2是最为有效的血压控制评估方法。

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    2020-06-16 howi
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    2019-08-01 一个字-牛

    学习了谢谢分享

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