Nat Commun:自噬紊乱易引发肠道疾病

2017-11-05 Flora 生物探索

11月2日,最新一篇发表在《Nature Communications》期刊的文章将炎症与一种基本的生物学过程——自噬关联起来,并构建了一种新关系,用于防治包括结肠癌、克罗恩病、溃疡性结肠炎在内的肠道疾病。

11月2日,最新一篇发表在《Nature Communications》期刊的文章将炎症与一种基本的生物学过程——自噬关联起来,并构建了一种新关系,用于防治包括结肠癌克罗恩病溃疡性结肠炎在内的肠道疾病。

自噬,是一种“自己吃自己”过程,是细胞维持物质周转的重要机制。当细胞内出现衰老的蛋白质、损坏的细胞器等废弃物时,自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用,从而确保细胞自身的代谢需要和某些细胞器的更新。

近期,来自于华威大学生命科学学院的Ioannis P. Nezis教授带领团队发现:当自噬功能紊乱时,会引发炎症,从而增加肠道疾病的发生风险。他们以果蝇为模型,发现了一个调控自噬的关键蛋白——Kenny。这一蛋白质含有一个motif,是启动蛋白“自噬分解”的关键元件。当自噬功能失调时,Kenny会聚集并引发炎症。

研究人员将Kenny标记上荧光,以便在显微镜下观察到自噬过程。结果发现,自噬失调会导致果蝇发生严重的炎症,特别是在肠道内,从而引发疾病,最终导致其寿命缩短一半!

对于人类而言,由自噬、炎症引发的肠道疾病和功能失调更为危险,因为我们体内的Kenny蛋白缺乏调控用的motif。

研究团队认为,理解这一关联,能够为肠道疾病找到更好的预防和治疗策略——调控细胞自噬平衡。他们建议,石榴、葡萄、梨、蘑菇、扁豆等食物中都含有激活自噬过程的天然化合物,有助于预防炎症和肠道疾病。


原始出处:
Tusco R, Jacomin AC, Jain A,et al.Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses.Nat Commun. 2017 Nov 2;8(1):1264. doi: 10.1038/s41467-017-01287-9.

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    2018-02-14 liuli5079
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    2018-03-18 一叶知秋
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    2017-11-08 微分

    学习了谢谢了

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2087188, encodeId=57ee208e188ec, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Wed Feb 14 00:35:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882603, encodeId=af17188260396, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Mar 18 13:35:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259827, encodeId=1b9525982e9d, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Wed Nov 08 23:53:57 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540631, encodeId=58881540631e6, content=<a href='/topic/show?id=e1f281e045e' target=_blank style='color:#2F92EE;'>#肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81704, encryptionId=e1f281e045e, topicName=肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d5513274388, createdName=guozhenyu, createdTime=Mon Nov 06 23:35:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259085, encodeId=0864259085f9, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 06 07:13:18 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258842, encodeId=ffd825884296, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Nov 05 10:17:29 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258828, encodeId=27bc258828bf, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Nov 05 09:47:23 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258801, encodeId=43822588015d, content=自噬.是一种[自己吃自己"过程.是细胞维持物质周转的重要机制.当细胞内出现衰老的蛋白质.损坏的细胞器等废弃物时.自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用.从而确保细胞自身的代谢需要和某些细胞器的更新., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 05 08:58:35 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2017-11-06 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2087188, encodeId=57ee208e188ec, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Wed Feb 14 00:35:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882603, encodeId=af17188260396, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Mar 18 13:35:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259827, encodeId=1b9525982e9d, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Wed Nov 08 23:53:57 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540631, encodeId=58881540631e6, content=<a href='/topic/show?id=e1f281e045e' target=_blank style='color:#2F92EE;'>#肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81704, encryptionId=e1f281e045e, topicName=肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d5513274388, createdName=guozhenyu, createdTime=Mon Nov 06 23:35:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259085, encodeId=0864259085f9, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 06 07:13:18 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258842, encodeId=ffd825884296, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Nov 05 10:17:29 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258828, encodeId=27bc258828bf, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Nov 05 09:47:23 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258801, encodeId=43822588015d, content=自噬.是一种[自己吃自己"过程.是细胞维持物质周转的重要机制.当细胞内出现衰老的蛋白质.损坏的细胞器等废弃物时.自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用.从而确保细胞自身的代谢需要和某些细胞器的更新., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 05 08:58:35 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2017-11-05 惠映实验室

    学习了.谢谢.

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2087188, encodeId=57ee208e188ec, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Wed Feb 14 00:35:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882603, encodeId=af17188260396, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Mar 18 13:35:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259827, encodeId=1b9525982e9d, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Wed Nov 08 23:53:57 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540631, encodeId=58881540631e6, content=<a href='/topic/show?id=e1f281e045e' target=_blank style='color:#2F92EE;'>#肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81704, encryptionId=e1f281e045e, topicName=肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d5513274388, createdName=guozhenyu, createdTime=Mon Nov 06 23:35:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259085, encodeId=0864259085f9, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 06 07:13:18 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258842, encodeId=ffd825884296, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Nov 05 10:17:29 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258828, encodeId=27bc258828bf, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Nov 05 09:47:23 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258801, encodeId=43822588015d, content=自噬.是一种[自己吃自己"过程.是细胞维持物质周转的重要机制.当细胞内出现衰老的蛋白质.损坏的细胞器等废弃物时.自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用.从而确保细胞自身的代谢需要和某些细胞器的更新., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Nov 05 08:58:35 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2017-11-05 明月清辉

    谢谢分享.学习了

    0

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    2017-11-05 榄枷檬

    自噬.是一种[自己吃自己"过程.是细胞维持物质周转的重要机制.当细胞内出现衰老的蛋白质.损坏的细胞器等废弃物时.自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用.从而确保细胞自身的代谢需要和某些细胞器的更新.

    0

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