Ann Rheum Dis:接种两剂COVID-19疫苗与类风湿性关节炎患者关节炎之间的关系

2021-10-23 MedSci原创 MedSci原创

目前的证据不支持接种COVID-19 mRNA或灭活病毒疫苗与可能的关节炎发作相关。

疫苗是控制全球COVID-19大流行的有效公共卫生举措。类风湿性关节炎(RA)患者更容易发生感染导致住院和生活质量下降。考虑到疫苗接种的好处大于风险,欧洲风湿病协会联盟 (EULAR)建议RA患者接受COVID-19疫苗,而无需对其正在进行的治疗方案进行重大调整。近日,风湿病领域顶级期刊Annals of the Rheumatic Diseases上发表了一篇研究文章,该研究旨在调查COVID-19完全疫苗接种(两次剂量)与可能的关节炎发作之间的关系。

研究人员从基于人群的电子病历中识别出类风湿关节炎(RA)患者,并将其分为BNT162b2(mRNA疫苗)、CoronaVac(灭活病毒疫苗)和非疫苗接种组。同时,研究人员使用倾向加权队列研究设计比较了疫苗接种后可能出现的关节炎风险。

根据发作期间的诊断记录,研究人员将可能的关节炎发作定义为与RA或反应性关节炎相关的住院和门诊咨询。研究人员对自COVID-19疫苗接种计划启动以来每周的风湿药处方进行了比较,以补充基于诊断的分析结果。

在5493名RA患者(BNT162b2:653人;CoronaVac:671人;未接种疫苗:4169人)中,倾向评分加权泊松回归显示关节炎发作与COVID-19疫苗接种之间没有显著关联(BNT162b2:调整后发病率比为0.86,95%置信区间0.73至1.01;CoronaVac:0.87(0.74至1.02))。自大规模疫苗接种计划启动以来,每周风湿病药物处方在三组之间没有显著差异(Kruskal-Wallis检验的所有p>0.1)。

由此可见,目前的证据不支持接种COVID-19 mRNA或灭活病毒疫苗与可能的关节炎发作相关。

原始出处:

Xue Li,et al.Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong.Ann Rheum Dis.2021.https://ard.bmj.com/content/early/2021/10/21/annrheumdis-2021-221571

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    2021-10-28 419040982

    oK!

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    2021-10-25 lmm397
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