CLIN CHEM LAB MED:血清钙蛋白作为类风湿关节炎生物标志物的分析前和分析混杂物分析

2020-02-12 MedSci MedSci原创

目前,仍需要一些更多的生物标志物来辅助类风湿关节炎(RA)的诊断和预后。我们的研究目的是评估血清钙蛋白作为RA炎症标志物的(分析前、分析和临床)表现。

目前,仍需要一些更多的生物标志物来辅助类风湿关节炎(RA)诊断和预后。我们的研究目的是评估血清钙蛋白作为RA炎症标志物的(分析前、分析和临床)表现。

研究人群包括463名首次咨询风湿病专家的风湿病患者(包括111RA患者和352名对照组患者)20名健康对照组患者和27感染性疾病患者。在血清中或血清和EDTA血浆(健康对照组和传染病组)中测量(使用四种不同的测定法)钙卫蛋白。 对于风湿病患者,测量C反应蛋白(CRP),红细胞沉降率(ESR),类风湿因子(RF)和抗环瓜氨酸肽抗体(ACPA)的结果。。

血液钙卫蛋白的的测定结果与基质有关,血清中的值高于血浆中的值。 RA患者的血清钙卫蛋白高于风湿病患对照组和健康对照组。 RA患者的血清钙卫蛋白水平低于感染性疾病的患者。 血清钙卫蛋白与疾病活动性相关(DAS评分)。 用于区分RA与对照的曲线下面积(AUC)对于CRP0.756,对于ESR0.714,对于钙卫蛋白为0.726-0.783。。

研究数据表明钙卫蛋白的测定依赖于分析和基质。血清钙卫蛋白与疾病活动有关。 必须进行其他(前瞻性)研究以进一步评估血钙卫蛋白的预后和诊断价值。

原始出处:

Lieve Van Hoovels,Bert Vander Cruyssen,Pre-analytical and analytical confounders of serum calprotectin as a biomarker in rheumatoid arthritis

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    2020-07-13 cy0324
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    2020-02-14 lmm397
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关节炎是运动系统最常见的疾病,也是导致病患丧失行动能力的重要原因之一。据统计,我国约有骨关节炎患者1.8亿,医疗费用占GDP的0.5%,给家庭和社会造成沉重负担,已成为世界性重大公共卫生问题和临床医学难题。关节内成分复杂,有滑膜、软骨、软骨下骨等多种组织结构,至今关节炎的发病机制尚未完全明确。以往研究显示滑膜巨噬细胞和巨噬细胞产生的炎性介质在关节炎的炎性和破坏性反应中发挥重要作用。