BMC Immunol:RF是ANCA相关性血管炎病情活动的炎症标志物

2018-01-26 北医三院姚中强 中国风湿病公众论坛

摘要 背景:有些ANCA相关性血管炎(AAV)患者也有类风湿因子(RF)阳性。然而AAV患者中其临床意义未明。本研究的目的是阐明AAV患者中存在RF与患者临床特点的相关性。

摘要 背景:有些ANCA相关性血管炎(AAV)患者也有类风湿因子(RF)阳性。然而AAV患者中其临床意义未明。本研究的目的是阐明AAV患者中存在RF与患者临床特点的相关性。

结果:纳入47名不伴有类风湿关节炎的AAV的患者。我们比较了RF阳性亚组 (n=29)和RF阴性亚组 (n=18)患者的临床特点。 RF阳性AAV患者的伯明翰血管炎活动性评分(BVAS)比RF阴性组更高(P=0.026)。RF阳性患者CRP 和 ESR水平高于RF阴性组(其P值分别为P=0.020和P=0.007)。IgM型RF滴度与 BVAS评分显着相关 (r=0.50, P=0.0004)。而且 IgM-RF滴度与CRP 水平(r=0.41, P=0.004)和ESR水平 (r=0.39, P=0.016)、IgM (r=0.36, P=0.016)和IgG (r=0.37, P=0.015)水平均显着相关。RF阳性组患者开始透析治疗的比例、使用机械通气比例和死亡率均高于RF阴性亚组。

结论:AAV患者中RF滴度与病情活动性显着相关,是其一种炎症标志物。AAV患者存在RF可作为一个预后差的指标。

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    2018-01-28 Boyinsh
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    2018-01-26 神功盖世

    0