Nat Med:背靠背,反义寡核苷酸治疗早衰症

2021-03-20 haibei MedSci原创

长期连续使用SRP-2001治疗可使小鼠寿命延长61.6%,并挽救了大动脉中血管平滑肌细胞的损失。这些结果为后续进行人体试验提供了依据。

Hutchinson-Gilford早衰综合征(HGPS)是一种罕见的加速衰老的疾病,其特点是心肌梗死或中风导致的过早死亡。它是由LMNA基因中的单核苷酸突变引起的,这些突变激活了一个隐性的剪接供体位点,导致产生一种有毒形式的层粘连蛋白A,即所谓的早老素。

最近,Nature Medicine杂志背靠背上线了两篇早衰症的基因疗法,其中Francis S. Collins团队提出了一种潜在的遗传治疗策略,即利用反义肽结合的磷脂酰亚胺形态低聚物(phosphorodiamidate morpholino oligomers,PPMO)来阻断突变转录物的致病性接合。在几个候选者中,PPMO SRP-2001可以最显著的减少患者成纤维细胞中的早老素转录物。静脉注射SRP-2001到HGPS的转基因小鼠模型中,可以使其主动脉中早老素的转录物显著减少,而主动脉是HGPS发病关键的靶组织。长期连续使用SRP-2001治疗可使小鼠寿命延长61.6%,并挽救了大动脉中血管平滑肌细胞的损失。这些结果为后续进行人体试验提供了依据。

在同期的Nature Medicine杂志,Tom Misteli团队也发文,其采用体外筛选和体内验证相结合的方法,系统地探索靶序列、骨架化学和作用机制的影响,以确定用于HGPS治疗的优化反义寡核苷酸(ASOs)。在198个ASOs的库中,最有效的ASOs靶向LMNA外显子12交界处,并通过非RNase H介导的机制发挥作用。

用优化的候选前导药物治疗可延长HGPS小鼠模型的寿命。早老素转录水平在体内稳健地降低,但早老素降低的程度在不同组织之间有所不同,这表明早老素在体内有较长的半衰期和组织特异性的周转

这些结果确定了一类新的HGPS治疗药物,并为HGPS疾病机制提供了深入的认识。

 

原始出处:

Madaiah Puttaraju et al. Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson–Gilford progeria syndrome. Nature Medicine (2021). 

Michael R. Erdos et al. A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome. Nature Medicine (2021).

 

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2022-01-15 liye789132251
  3. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-21 xsm918
  4. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1700427, encodeId=8f9f1e004279b, content=<a href='/topic/show?id=2f93465966d' target=_blank style='color:#2F92EE;'>#寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46596, encryptionId=2f93465966d, topicName=寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=491a30091205, createdName=DEXTER3149, createdTime=Fri Jun 18 11:09:52 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885050, encodeId=91dd1885050dc, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 15 09:09:52 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945658, encodeId=6e751945658fe, content=<a href='/topic/show?id=a9fa62150e8' target=_blank style='color:#2F92EE;'>#核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62150, encryptionId=a9fa62150e8, topicName=核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun Mar 21 07:09:52 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530841, encodeId=46191530841c4, content=<a href='/topic/show?id=f9cd5950630' target=_blank style='color:#2F92EE;'>#早衰症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59506, encryptionId=f9cd5950630, topicName=早衰症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8212147736, createdName=zhangfenasdf, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575379, encodeId=203715e537944, content=<a href='/topic/show?id=03753e66414' target=_blank style='color:#2F92EE;'>#反义寡核苷酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37664, encryptionId=03753e66414, topicName=反义寡核苷酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfc816121587, createdName=fyxzlh, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610970, encodeId=3c0016109e075, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Mar 22 07:09:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949757, encodeId=de7c949e57d9, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Mar 20 17:43:50 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
    2021-03-20 jyzxjiangqin

    好文章!

    0

相关资讯

勃林格殷格翰携手克睿基因,共同开发下一代具有突破性的基因疗法

今天(1月18日),勃林格殷格翰和苏州克睿基因生物科技有限公司(以下简称克睿基因)共同宣布,双方将通过克睿基因专有的VELP?平台开发新型腺相关病毒(AAV)载体,用于下一代基因治疗。

蓝鸟生物继基因疗法致癌后表示:不可能导致白血病,或将恢复临床研究

近日,在积极配合美国食品药品监督管理局(FDA)的审查后,蓝鸟生物(bluebird bio)宣布,

Blood:B型血友病基因疗法BAX 335的临床试验结果

B型血友病是由F9基因变异导致的凝血因子IX (FIX)活性不足引起的。基因疗法有可能通过将功能性人类F9基因导入肝细胞来维持B型血友病患者的治疗性FIX水平。

NEJM:基因疗法Evrysdi(risdiplam)治疗1型脊髓性肌萎缩婴儿,取得阳性数据

Evrysdi治疗组患者的SMN蛋白在治疗12个月时比的基线增加1.9倍。

遗传性视网膜疾病,基因疗法OCU400获得欧盟“孤儿药称号”

制药公司Ocugen近日宣布,欧洲委员会(EC)已授予基因疗法OCU400“孤儿药称号”,用于治疗遗传性视网膜疾病(IRD)色素性视网膜炎和Leber先天性黑矇。

我国科研人员发现可延缓衰老的新型“基因疗法”

人类基因组中有多少衰老调控基因?其参与衰老调控的分子机制是什么?能否在分子层面“操控”这些基因以延缓机体衰老?我国科研人员的一项最新成果对这些衰老领域的重要问题给出新的见解。