JCO:血液系统恶性肿瘤干细胞移植后认知功能

2017-12-20 MedSci MedSci原创

清髓性异体干细胞移植(HCT)后认知功能损害已得到公认,但是低强度异体或自体HCT后对认知功能的影响尚不清楚。JCO近期发表了一篇文章研究这一问题。

清髓性异体干细胞移植(HCT)后认知功能损害已得到公认,但是低强度异体或自体HCT后对认知功能的影响尚不清楚。JCO近期发表了一篇文章研究这一问题。

研究共纳入477例接受HCT的患者(236例自体移植,128例低强度异体移植,113例清髓性异体移植),所有患者在HCT前及HCT后6个月,1年2年和3年接受标准化的神经心理学测试。在相应时间点对99例正常对照进行检测。纳入的接受HCT的患者中位年龄52岁,对照组中位年龄55岁。对照组,自体移植组和低强度HCT组进行HCT后评分相似。接受清髓性HCT的患者在执行功能,语速,处理速度,听觉记忆和精细动作方面的HCT后评分显着低于对照组。低强度HCT组HCT前到HCT后6个月评分未改变,但清髓性HCT后精细动作评分显着下降。低强度HCT组HCT前评分到HCT后3年评分显着下降,主要表现在执行功能,语言流畅性和工作记忆方面。年龄大,男性,教育水平低,收入和认知储备与HCT后认知损伤有关。HCT后3年,18.7%的自体移植患者和35.7%的异体HCT患者出现广泛性认知损伤。

文章最后认为,与对照组相比,进行清髓性异体HCT患者出现认知功能显着降低。进行低强度异体HCT的患者延迟出现认知功能下降。自体HCT的患者认知功能通常不受影响。该研究发现了已出现功能损伤的亚组,可能有助于进行针对性干预。

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    2018-05-05 lidong40
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    2018-08-16 三不猴

    谢谢分享

    0

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    2017-12-26 wxl882001

    学习一下

    0

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    2017-12-21 thlabcde

    好资料学习了!

    0

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    2017-12-21 戒馋,懒,贪

    谢谢分享学习了

    0

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    2017-12-20 三生有幸9135

    学习一下谢谢分享

    0

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《2017年意大利共识指南:血液系统恶性肿瘤以及接受造血干细胞移植患者HBV再激活的筛查、监测、预防和预防性治疗的建议》摘译

HBV再激活与血液系统恶性肿瘤/造血干细胞移植(HSCT)患者的高发病率和病死率相关,但关于这个问题的证据是有限的。本指南将提供该类患者的HBV筛查、监测、预防、治疗和疫苗接种的建议。综合意大利不同医学领域学会在同期刊物发表的关于血液病患者和接受HSCT患者HBV 感染的系统文献综述(至2016 年12 月31日)总结出该指南。

CLIN CANCER RES:Fenretinide静脉给药治疗复发或难治性血液系统恶性肿瘤

体外实验证实Fenretinide对淋巴细胞性白血病细胞系具有显著毒性作用,同时对成纤维细胞、外周血单核细胞以及髓系祖细胞的毒性很小,表明其在血液系统恶性肿瘤中具有治疗潜力。CLIN CANCER RES近期发表了一篇文章,研究Fenretinide静脉途径给药治疗血液系统恶性肿瘤的最大耐受剂量(MTD),剂量限制毒性(DLT)以及药代动力学。

Eur Respir J:实体肿瘤和血液系统恶性肿瘤患者结核病的风险!

考虑到癌症患者免疫抑制的时间有限,并且因为预期寿命的降低,会减少结核病的终生累积的风险,但儿童,而不是成人,似乎存在足够的风险水平来全面地筛查LTBI。

BJC:宫内暴露于电离辐射,会增加后代血液系统恶性肿瘤风险

子宫内暴露于低剂量的电离辐射是否会增加血液系统恶性肿瘤的终生风险?目前仍不清楚。 我们合并了两个队列的数据:来自乌拉尔南部大型核设施的女性工人后代,生活在核事故/垃圾污染的捷恰河周围的的女性后代。有详细的剂量学数据。 队列合并后共有19 536例参与者,共计700 504人年的随访时间,随访最高到61岁,共发生了58例血液系统恶性肿瘤事件和36例死亡事件。 子宫内暴露于电离辐射的