JAHA:结节病患者心衰、房室传导阻滞和室性心动过速的流行病学特征

2021-02-19 MedSci原创 MedSci原创

结节病是一种肉芽肿性疾病,通常影响肺部功能,尽管对心脏的影响也很常见。然而,这些结局风险和预测它们的特征在很大程度上仍是未知的。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨

结节病是一种肉芽肿性疾病,通常影响肺部功能,尽管对心脏的影响也很常见。然而,这些结局风险和预测它们的特征在很大程度上仍是未知的。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨有无结节病患者的心衰、房室传导阻滞和室性心动过速的流行病学特征。

研究人员使用了2005年至2015年期间加州健康规划与发展办公室门诊手术、急诊或住院患者数据库确定了年龄超过21岁的居民。研究人员分别确定了结节病对心衰、房室传导阻滞和室性心动过速的风险,并与社会保障死亡指数链接以确定总体死亡率。

在22527964名加州居民中,研究人员发现了19762名(0.09%)结节病患者。在所有危险因素中,结节病是心衰(风险比[HR]为11.2;95%CI为10.7-11.7)、房室传导阻滞(HR为117.7;95%CI为103.3-134.0)和室性心动过速(HR为26.1;95%CI为24.2-28.1)最强的预测因素。

任何形式的心脏受累都能预测各种结局。结节病与死亡率增加之间的关联中大约有22%(95%CI为18%-26%)的比例可以用至少伴有一种心血管结局来解释。

由此可见,结节病作为心衰、房室传导阻滞和室性心动过速的预测因子,其风险相关程度超过了所有已知的危险因素。对结节病患者进行监测和预测这些结局十分有必要,对于心衰、房室传导阻滞或室性心动过速患者,应慎重考虑结节病诊断

原始出处:

David G. Rosenthal.et al.Heart Failure, Atrioventricular Block, and Ventricular Tachycardia in Sarcoidosis.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017692

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471131, encodeId=cd4c14e1131b7, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Sun Feb 21 12:53:17 CST 2021, time=2021-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925559, encodeId=8a4e92555932, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210219/ed4350faaf834cbbaaee2ccfc31248b1/a3fec57f1c9d429c91e661c2f0b6cba8.jpg, createdBy=9dfd5402356, createdName=ms6000001236844761, createdTime=Fri Feb 19 22:02:47 CST 2021, time=2021-02-19, status=1, ipAttribution=)]
    2021-02-22 12131f9bm89(暂无昵称)

    总结的好!

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471131, encodeId=cd4c14e1131b7, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Sun Feb 21 12:53:17 CST 2021, time=2021-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925559, encodeId=8a4e92555932, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210219/ed4350faaf834cbbaaee2ccfc31248b1/a3fec57f1c9d429c91e661c2f0b6cba8.jpg, createdBy=9dfd5402356, createdName=ms6000001236844761, createdTime=Fri Feb 19 22:02:47 CST 2021, time=2021-02-19, status=1, ipAttribution=)]
    2021-02-21 zhaohui6731
  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471131, encodeId=cd4c14e1131b7, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Sun Feb 21 12:53:17 CST 2021, time=2021-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925559, encodeId=8a4e92555932, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210219/ed4350faaf834cbbaaee2ccfc31248b1/a3fec57f1c9d429c91e661c2f0b6cba8.jpg, createdBy=9dfd5402356, createdName=ms6000001236844761, createdTime=Fri Feb 19 22:02:47 CST 2021, time=2021-02-19, status=1, ipAttribution=)]
    2021-02-21 xugumin
  8. 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createdName=ms6000001236844761, createdTime=Fri Feb 19 22:02:47 CST 2021, time=2021-02-19, status=1, ipAttribution=)]
    2021-02-19 ms6000001236844761

    学习了

    0

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