JCEM:代谢综合症及其组分对骨折的影响

2021-02-04 MedSci原创 MedSci原创

代谢综合症(MetS)及其组分与骨折之间的关联存在性别差异。具有腹部肥胖的女性骨折的风险增加,而具有较高FPG的男性风险较低。

代谢综合症(MetS)与骨折风险之间的关系尚有争议。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探讨代谢综合征(MetS)与骨折风险之间的关系。

在中位随访15.9年期间,研究人员旨在确定代谢综合征(MetS)及其成分对骨折风险的影响。7520名30岁以上的参与者(4068名女性)被纳入研究。结果采用多变量Cox比例风险回归分析进行数据分析。

男性和女性参与者Mets的患病率分别为40.0%和40.4%。在随访期间,研究人员共观察到305例需要住院的骨折事件(男性=152)。男性和女性MetS患者骨折的多变量风险比(HR)和95%置信区间(CI)分别为0.72(0.49-1.05,p=0.08)和1.38(0.96-1.98,p=0.08)。在完全调整的模型中,高空腹血糖(FPG)男性往往具有较低的骨折风险[0.67(0.44-1.02,P=0.06)];在女性中,腰围(WC)较大与较高的骨折风险相关[2.40(1.55-3.73)]。在汇总样本中年龄50岁以上的人群,MetS并没有影响骨折的风险,但较大的WC与较高的风险相关[1.58(1.07-2.33)]。对于髋/骨盆骨折,腹部肥胖(并非MetS)也是一个重要且独立的危险因素。

由此可见,Mets及其组分与骨折之间的关联存在性别差异。具有腹部肥胖的女性骨折的风险增加,而具有较高FPG的男性风险较低

原始出处:

Atieh Amouzegar.et al.The Role of Metabolic Syndrome and its Components in Incident Fracture: A 15-year follow-up among the Iranian Population.JCEM.2021.https://doi.org/10.1210/clinem/dgab023

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    2021-07-16 achengzhao
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    2021-06-07 Lee4204

    好好学习,天天向上

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    2021-04-01 smallant2015
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    2021-02-05 Jessica

    对于30岁以上的女性,腹部肥胖会增加骨折的风险!#骨折#

    0

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