Nature Metabolism:铁证如山!多所英美**学府研究证实饥饿感由血糖引起

2021-04-13 Oranhgy MedSci原创

在进食后几个小时,血糖水平出现大跌的人,最终会比其他人饥饿感更强。

近期,伦敦国王学院和健康科学公司ZOE的研究团队(包括来自哈佛医学院、哈佛T.H。陈公共卫生学院、麻省总医院、诺丁汉大学、利兹大学和瑞典隆德大学的科学家)联合发表在《自然代谢》上的一项研究表明,在进食后几个小时,血糖水平出现大跌的人,最终会比其他人饥饿感更强。

该研究结果来自世界上最大的正在进行的营养研究计划PREDICT,该计划关注真实生活环境中对食物的反应,寻找即使在控制卡路里的饮食中也难以减肥的原因,以及在饮食和健康方面了解个人新陈代谢的重要性。

研究团队收集了1070人在两周内吃完标准化早餐和自由选择的餐食后的血糖反应和其他健康标志物的详细数据,共有8000多份早餐和7万多份餐食。标准早餐均以松饼为主,在控制相同的热量前提下,在碳水化合物、蛋白质、脂肪和纤维等方面的成分有所不同。

参与者佩戴贴式连续血糖监测仪(CGM)来测量他们在整个研究期间的血糖水平,以及一个可穿戴设备来监测活动和睡眠。通过收集应用程序记录饥饿感确切的时间。此外,参与者还进行了空腹血糖反应测试(口服葡萄糖耐量试验),以测量他们的身体对糖的处理情况。

在比较参与者吃同样的测试餐时的情况后,研究人员发现参与者之间的血糖反应有很大差异。以往研究进食后的血糖,都集中在餐后头两个小时内水平的升降方式,即所谓的血糖峰值。然而,在分析数据后,PREDICT团队注意到,一些人在这个初始峰值后的2-4小时内经历了显著的 "糖分骤降",他们的血糖水平在回升之前迅速降至基线以下。

参与者血糖情况

进食后血糖大幅下降的人比其他人饥饿感增加了9%。在早餐后的3-4小时内,这些进食后会出现血糖水平大幅下降的人会多摄入75卡路里的热量,而全天范围内,他们更是多摄入了约312卡路里的热量。这种行为模式可能会导致一年中体重增加20磅(约等于9公斤)。

clevelandclinic

事实上,此前人们一直怀疑血糖水平在控制饥饿方面发挥着重要作用,但之前的各种研究结果并不确定。而如今该研究结果很明显地表明,与进食后的初始血糖峰值反应相比,糖分的下降更能预测饥饿感和随后的卡路里摄入量,这也改变了我们对血糖水平和所吃食物之间关系的思考。

参考文献:

Wyatt, P., Berry, S.E., Finlayson, G. et al. Postprandial glycaemic dips predict appetite and energy intake in healthy individuals. Nat Metab (2021).  doi.org/10.1038/s42255-021-00383-x

 

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    2021-11-04 guojianrong
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    2021-05-23 liye789132251
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    2021-04-15 xlysu
  5. 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    2021-04-15 xlysu
  6. 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    2021-04-15 闆锋旦
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    2021-04-14 GY058774

    有意义

    0

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    2021-04-13 我要当大牛

    一个疑问🤔️糖尿病人血糖那么高,他们为什么还多饮多食?

    1

    展开1条回复
  10. 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    2021-04-28 一闲

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既往研究显示,较高浓度的脂肪酸生物标记物(乳制品脂肪摄入量)与较低的2型糖尿病发病率有关。然而,很少有试验评估乳制品对血糖稳态的影响,包括发酵或全脂乳制品。

Diabetes:血糖、认知功能、大脑结构与痴呆之间的关系

很少证据表明T2D或外周血糖的遗传工具与中年认知和大脑结构的指标之间存在因果关系。

JAHA:术前血糖和糖化血红蛋白水平与非心脏手术后心肌损伤之间的关系

术前高血糖与MINS和30天死亡率相关,而HbA1c与此无关。在非心脏手术患者中,短期内控制血糖可能比长期控制血糖更重要。

拓展阅读

JGH:持续性幽门螺杆菌感染会导致空腹血糖水平升高

在我国,幽门螺旋杆菌的感染率可高达40-60%,其中的大部分感染者在感染后并没有任何症状,少部分感染者可有消化不良的症状。

心血管疾病死亡率超40%!7大生活方式及血压、血脂、血糖管理不容忽视

《医学新视点》基于心血管疾病的生活方式干预,血压、血脂、血糖管理等进行介绍,以餮读者。

“三高”共存下,管理好血糖、血压和血脂,这2大治疗策略是关键

近期,《“三高”共管规范化诊疗中国专家共识(2023版)》发布,该指南结合中国临床实践,旨在积极推广“三高”共管的理念,提升临床医生的“三高”共管技能。

Pediatr Obes:食用西瓜搅拌物会降低超重或肥胖儿童的体重指数、体重指数百分位数、体脂和 HbA1c

本研究的目的是检查全混合西瓜(BWM)消费对心脏代谢危险因素的影响。

快步健走or散步?BMJ子刊:有趣有效又安全!这项运动的确更适合老人预防心脏病!

BMJ Open Sport & Exercise Medicine:在健康老年人中,打高尔夫球与北欧式健行和步行对心脏代谢标志物的急性生理影响的比较效果:一项随机交叉研究。

新研究:结婚可能有助于人们保持较低的血糖水平

结果表明,无论配偶之间关系如何,婚姻/同居关系都与HbA1c水平成反比。同样,这些关系似乎对高于糖尿病前期阈值(pre-diabetes)的HbA1c水平有保护作用。