JAHA:终末期肾病患者感染性心内膜炎住院治疗和预后

2021-09-28 MedSci原创 MedSci原创

IE与ESKD患者的不良预后相关,尤其是长期预后。与没有ESKD的患者相比,ESKD患者在IE住院治疗后1年内死亡的可能性是其两倍,3年内死亡的可能性是其三倍。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员调查了苏格兰需要透析或肾移植的终末期肾病(ESKD)患者因感染性心内膜炎(IE)住院患者的临床特征、微生物学检查结果以及短期和长期结局。

在这项将全国住院和死亡率数据联系起来的基于人群的回顾性队列研究中,研究人员确定了1990年1月1日至2014年12月31日期间苏格兰的ESKD病史和IE住院患者。从2008年1月1日起,IE住院患者还与国家微生物学检查结果数据相关联。多变量Logistic回归,调整患者人口统计学和合并症,评估了ESKD与1年和3年全因死亡之间的关联。

在1990年至2014年期间的7638次IE住院事件中,210名ESKD患者占2.8%(216/7638),7303名非ESKD患者占97.2%(7422/7638)。自2008年起,42%(950/2267)的IE住院患者的血培养结果阳性。分别在25.9%(21/81)和12.8%(280/2186)的ESKD患者中分离出金黄色葡萄球菌(P=0.002)。

ESKD与1年(44.9% vs. 31.4%;调整后的比值比[aOR]为2.47,95%CI为1.85-3.30;P<0.001)和3年(63.9% vs. 42.8%;aOR为3.77;95%CI为2.79–5.12;P<0.001)死亡几率增加相关。

由此可见,IE与ESKD患者的不良预后相关,尤其是长期预后。与没有ESKD的患者相比,ESKD患者在IE住院治疗后1年内死亡的可能性是其两倍,3年内死亡的可能性是其三倍。

原始出处:

Peter J. Gallacher.et al.Infective Endocarditis Hospitalizations and Outcomes in Patients With End‐Stage Kidney Disease: A Nationwide Data‐Linkage Study.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022002

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    2021-09-30 zhaohui6731
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