Clin Trans Gastroenterology:溃疡性结肠炎患者外周血单核细胞计数与黏膜愈合的关系

2021-11-24 MedSci原创 MedSci原创

溃疡性结肠炎是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病,病变局限于大肠黏膜及黏膜下层。

溃疡性结肠炎 (UC) 的临床特征是疾病反复复发和缓解,在临床实践中发现粘膜愈合 (MH) 与临床复发、住院和手术率以及结直肠癌的发病率呈负相关。因此,MH 是 UC 的治疗目标。随着亚洲国家 UC 患者数量的增加,因此,对快速、可重复、低廉和临床有用的 MH 血清生物标志物的需求越来越强烈。有研究显示外周血白细胞亚型,包括单核细胞,与黏膜先天免疫失调相关,也是UC发病机制的关键因素。然而,UC 患者外周血单核细胞计数与 MH 之间的关联尚未得到证实。

 

本项研究总共纳入了272名日本 UC 患者,在隔夜禁食后的早晨进行单核细胞计数。基于患者的单核细胞计数水平将患者分为高中低三分位数。然后研究人员从从患者的病历中获得临床缓解信息,对于MH的评估是使用梅奥内窥镜评分进行诊断的。

 

研究结果显示溃疡性结肠炎患者的平均单核细胞计数为360.1±155.3/mm3。临床缓解率、MH 和完全 MH 率分别为 61.0%、66.2% 和 27.9%。高单核细胞计数与临床缓解、MH 和完全 MH 显着负相关( [OR] :0.45 ;95% [CI]:0.23-0.89]。研究人员还根据患者的C 反应蛋白 (CRP) 水平进行分类;在低 CRP 组 (<0.1 mg/dL) 中,高单核细胞计数与完全 MH 独立负相关,但与临床缓解或 MH 无关(OR 0.33 [95% CI: 0.10–0.92],P = 0.027)。在高 CRP 组中,单核细胞计数与临床结果之间没有关联。

 

研究最后作者说道外周血单核细胞计数可能与溃疡性结肠炎患者的临床缓解、部分 MH 和 完全MH显着负相关。在CRP水平较低的 UC 患者中,外周血单核细胞计数可能仅与 MH 显着负相关。因此,在 CRP 低的 UC 患者中,外周血单核细胞计数可能作为 MH 的血液标志物。

原始出处:

Furukawa. Et al. Association Between Peripheral Blood Monocyte Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis. Clinical and Translational Gastroenterology. 2021.

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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42822, encryptionId=0c4742822df, topicName=外周血单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=316c73, createdName=caoliehu, createdTime=Wed Jun 15 09:54:03 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695254, encodeId=881c16952543f, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Tue Jan 11 14:54:03 CST 2022, time=2022-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299161, encodeId=e87e1299161cb, content=<a href='/topic/show?id=2b85362063c' target=_blank style='color:#2F92EE;'>#单核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36206, encryptionId=2b85362063c, topicName=单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505352, encodeId=6b5c150535237, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520091, encodeId=0fac152009180, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
    2022-01-10 bsmagic9140
  5. [GetPortalCommentsPageByObjectIdResponse(id=2065473, encodeId=df4120654e378, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun May 29 11:54:03 CST 2022, time=2022-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994925, encodeId=29331994925cd, content=<a href='/topic/show?id=bd3f10325926' target=_blank style='color:#2F92EE;'>#黏膜愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103259, encryptionId=bd3f10325926, topicName=黏膜愈合)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=2b85362063c' target=_blank style='color:#2F92EE;'>#单核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36206, encryptionId=2b85362063c, topicName=单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505352, encodeId=6b5c150535237, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520091, encodeId=0fac152009180, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
    2022-01-05 许安
  6. 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  7. 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CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520091, encodeId=0fac152009180, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu Nov 25 00:54:03 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
    2022-01-11 nymo
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  9. 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    2021-11-25 snowpeakxu

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