Int J Mol Sci:间歇性缺氧、高脂饮食和半乳糖注射刺激所引起的短期听力损失

2020-10-08 AlexYang MedSci原创

年龄相关的听力损失(ARHL)是老年人最常见的感觉障碍,与衰老和氧化应激诱导的线粒体功能障碍导致的听毛细胞死亡有关。虽然转基因小鼠和长期老化诱导培养已用于研究ARHL,但目前还没有可以通过间歇性环境变

年龄相关的听力损失(ARHL)是老年人最常见的感觉障碍,与衰老和氧化应激诱导的线粒体功能障碍导致的听毛细胞死亡有关。虽然转基因小鼠和长期老化诱导培养已用于研究ARHL,但目前还没有可以通过间歇性环境变化刺激的ARHL动物模型。

最近,有研究人员通过诱导持续的氧化应激促进细胞短期老化建立了ARHL动物模型,根据听力损失诱导的表型和老化相关因子的表达来确定模型。研究发现,双重和三重暴露条件下,听力损失的发生率明显高于间歇性缺氧条件、高脂饮食(HFD)或单独注射D-半乳糖。持续的氧化应激和HFD加速了细胞衰老。研究人员还观察到了Ucp2的增加,该蛋白通常在线粒体功能障碍期间表达。另外,ARHL相关因子Cdh23、SLC26a4、Kcnq4、Myo7a和Myo6在听觉器官细胞中的表达均被氧化应激改变。研究人员还发现,间歇性缺氧、HFD和半乳糖注射在短期内加速了细胞老化。

缺氧,HFD和GI的单一暴露,双重暴露和三重暴露情况下的阈值比较

最后,研究人员指出,能够反映间歇性环境变化影响的听力损失动物模型的发展将有利于未来对ARHL的研究。

原始出处:

Dong Jun Park , Sunmok Ha , Jin Sil Choi et al. Induced Short-Term Hearing Loss due to Stimulation of Age-Related Factors by Intermittent Hypoxia, High-Fat Diet, and Galactose Injection. Int J Mol Sci. Sep 2020

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    2020-10-10 ms3000000449926787

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    2020-10-10 ysjykql
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    2020-10-10 pcw111
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    2020-10-10 minzju5058

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