银屑病关节炎头对头实验中,诺华的IL-17单抗Cosentyx与Humira相比未能实现统计学意义的改善

2019-11-03 不详 MedSci原创

在银屑病关节炎(PsA)的头对头试验中,诺华的白细胞介素-17单抗Cosentyx(secukinumab)未能显示出超过AbbVie的Humira(adalimumab)的显着优势。尽管Cosentyx与Humira相比显示出更高的结果,但勉强错过了EXCEED试验主要终点,即ACR 20具有统计学意义的优越性。

在银屑病关节炎(PsA)的头对头试验中,诺华的白细胞介素-17单抗Cosentyx(secukinumab)未能显示出超过AbbVie的Humira(adalimumab)的显着优势。尽管Cosentyx与Humira相比显示出更好的治疗结果,但勉强错过了EXCEED试验主要终点,即ACR 20具有统计学意义的优越性。

这项研究是Cosentyx与Humira在未接受生物疗法治疗的活动性PsA患者中进行的为期52周的3b期临床研究,涉及800多名参与者。在预先指定的敏感性分析中,Cosentyx在PsA特定终点方面显示出比Humira具有统计学意义的优势。该试验还显示了Consentyx的一致且有利的安全性。

诺华公司免疫学,肝病学和皮肤病学全球研发部门负责人埃里克·休斯(Eric Hughes)表示"EXCEED是有史以来首个针对银屑病关节炎的单一疗法头对头试验"。

这些结果对诺华制药公司来说是一个打击,尤其是在诺华制药公司于本月初公布了Cosentyx针对非放射线轴性脊柱关节炎(nr-axSpA)的积极成果之后。在该试验中,Cosentyx达到了主要终点,其特征是患者总体评估,疼痛,功能和炎症改善了至少40%。

白细胞介素17抑制剂已被批准用于该病的另一种形式,强直性脊柱炎。它也被批准用于牛皮癣关节炎和斑块状牛皮癣。

原始出处:


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    2020-08-14 smallant2002
  4. 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encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282776, encodeId=a1ea1282e7658, content=<a href='/topic/show?id=2df29190553' target=_blank style='color:#2F92EE;'>#诺华#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91905, encryptionId=2df29190553, topicName=诺华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374433, encodeId=916013e443356, content=<a href='/topic/show?id=1727963861' target=_blank style='color:#2F92EE;'>#IL-17#</a>, beContent=null, objectType=article, channel=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508255, encodeId=6383150825524, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=)]
    2019-11-05 lmm397
  5. 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  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508255, encodeId=6383150825524, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=)]
    2019-11-05 fzwish20000
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442304, encodeId=e35a144230490, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508125, encodeId=c8671508125d8, content=<a href='/topic/show?id=8b7751152d' target=_blank style='color:#2F92EE;'>#Cosentyx#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5115, encryptionId=8b7751152d, topicName=Cosentyx)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508255, encodeId=6383150825524, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=)]
    2019-11-05 zhouqu_8
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442304, encodeId=e35a144230490, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508125, encodeId=c8671508125d8, content=<a href='/topic/show?id=8b7751152d' target=_blank style='color:#2F92EE;'>#Cosentyx#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5115, encryptionId=8b7751152d, topicName=Cosentyx)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508255, encodeId=6383150825524, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Nov 05 11:25:00 CST 2019, time=2019-11-05, status=1, ipAttribution=)]
    2019-11-05 siiner
  9. 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  10. 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    2019-11-05 jjjiang0202

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J Rheumatol:苏金单抗在银屑病关节炎和强直性脊柱炎患者中的免疫原性

在PsA和AS患者中,使用苏金单抗的免疫原性发生率低(<1%)。

J Rheumatol:银屑病关节炎合并症与生活质量的关系

合并症类型比合并症数量的影响更大。PsA患者中的焦虑与QoL独立相关。

强生向欧洲药品管理局提交申请,寻求扩大其IL-23单抗Tremfya用于治疗银屑病关节炎

强生已向欧洲药品管理局(EMA)提交了II型变更申请,以寻求扩大其白细胞介素-23单抗Tremfya(guselkumab)用于治疗成人活动性银屑病关节炎(PsA)。一旦获批,将成为该药物在欧盟的第二项适应症。

Clin Exp Rheumatol:阿普斯特在多中心银屑病关节炎队列中的疗效

阿普斯特主要用于有合并症,从而不能使用生物制剂的少关节PsA患者。疗效和安全性与临床试验一致。

J Rheumatol:定义反映最小疾病活动状态的银屑病关节炎疾病活动性评分(PASDAS)

PASDAS评分<3.2时反映MDA。这项研究在外部验证了既往提出的区分低、中、高疾病活动的PASDAS阈值。

J Rheumatol:银屑病关节炎的疲劳是由炎症、病程和慢性疼痛引起的

PsA患者的疲劳是由临床炎症因素、病程和没有炎症的慢性疼痛引起的。