Eur J Cancer:鉴别高复发风险的I/IIA期黑色素瘤的新模型

2020-11-25 MedSci原创 MedSci原创

辅助治疗可延长III期黑色素瘤患者的无复发存活期(RFS),以至于IIIA/B期黑色素瘤的5年黑色素瘤特异性存活率(MSS)可达到83-93%,与IIB/C期的患者的相近(82-87%)。目前,I/I

辅助治疗可延长III期黑色素瘤患者的无复发存活期(RFS),以至于IIIA/B期黑色素瘤的5年黑色素瘤特异性存活率(MSS)可达到83-93%,与IIB/C期的患者的相近(82-87%)。目前,I/IIA期皮肤黑色素瘤(CM)患者无辅助治疗的指征,即使这类患者的复发风险尚不明确。因此,临床上亟需可鉴别高风险的I/IIA期患者的诊断工具。

Eggermont等新开发的一种结合了临床病理和基因表达变化(CP-GEP)的模型,以帮助临床识别具有高疾病复发风险的I/IIA期黑色素瘤患者。评估该模型鉴别高风险患者亚群能力的研究结果于近期发表在了《European Journal of Cancer》杂志上。

所有患者的整体存活预后

该分析队列纳入了837位原发性CM患者来评估CP-GEP模型的预测价值。CP-GEP模型结合了Breslow的厚度和患者年龄,以及原发性肿瘤中八个基因的表达。此外,一个包含了580位I/IIA期患者的特殊队列,被根据他们的复发风险分成了CP-GEP高风险组和CP-GEP低风险组。该研究的主要终点是五年无复发存活率(RFS)。

580位特殊队列患者的存活预后

在I/IIA期黑色素瘤患者中,CP-GEP鉴定出的高风险患者(47%)的五年RFS低于低风险组的(74% vs 89%;HR 2.98,95% CI 1.78-4.98,p<0.0001)。在高风险患者亚组中,复发事件多发生在前3年。

总之,CP-GEP模型可用于筛选高复发风险的I/IIA期黑色素瘤患者,这些患者或可从辅助治疗中获益。

原始出处:

Alexander M.M. Eggermont, et al. Identification of stage I/IIA melanoma patients at high risk for disease relapse using a clinicopathologic and gene expression model. European Journal of Cancer. October 05, 2020.

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    2020-12-24 sunylz
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1680700, encodeId=2a931680e004a, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Dec 24 04:56:13 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905567, encodeId=aac5190556e07, content=<a href='/topic/show?id=0eb34259ea1' target=_blank style='color:#2F92EE;'>#复发风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42597, encryptionId=0eb34259ea1, topicName=复发风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Tue Feb 23 12:56:13 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559034, encodeId=b1541559034c5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 27 05:56:13 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565043, encodeId=52ff156504301, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 27 05:56:13 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902438, encodeId=f34b90243889, content=深度好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201201/cade54d2b9b64947848f5d0b9b288c9a/6c5d0b4cc9cd44a7851dffb52b24dc89.jpg, createdBy=fdb44694234, createdName=392534278, createdTime=Thu Nov 26 11:17:43 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902255, encodeId=4abb902255e2, content=厉害<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35fc5438461, createdName=ms3000000060905474, createdTime=Wed Nov 25 19:50:11 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047866, encodeId=e871104e866a8, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Nov 25 17:56:13 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902226, encodeId=593f902226ba, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9cb5438426, createdName=ms5000001559827487, createdTime=Wed Nov 25 16:59:17 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-26 392534278

    深度好文章

    0

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    2020-11-25 ms3000000060905474

    厉害#学习#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1680700, encodeId=2a931680e004a, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Thu Dec 24 04:56:13 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905567, encodeId=aac5190556e07, content=<a href='/topic/show?id=0eb34259ea1' target=_blank style='color:#2F92EE;'>#复发风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42597, encryptionId=0eb34259ea1, topicName=复发风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Tue Feb 23 12:56:13 CST 2021, time=2021-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559034, encodeId=b1541559034c5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 27 05:56:13 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565043, encodeId=52ff156504301, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 27 05:56:13 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902438, encodeId=f34b90243889, content=深度好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201201/cade54d2b9b64947848f5d0b9b288c9a/6c5d0b4cc9cd44a7851dffb52b24dc89.jpg, createdBy=fdb44694234, createdName=392534278, createdTime=Thu Nov 26 11:17:43 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902255, encodeId=4abb902255e2, content=厉害<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35fc5438461, createdName=ms3000000060905474, createdTime=Wed Nov 25 19:50:11 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047866, encodeId=e871104e866a8, content=梅斯里提供了很多疾病的模型计算公式,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Nov 25 17:56:13 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902226, encodeId=593f902226ba, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9cb5438426, createdName=ms5000001559827487, createdTime=Wed Nov 25 16:59:17 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-25 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0

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    2020-11-25 ms5000001559827487

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