Hypertension:主动脉根部直径与动脉硬化

2021-10-11 MedSci原创 MedSci原创

较高的中心脉压与较高的颈股脉搏波速度(CFPWV)与心血管疾病(CVD)风险增加有关。男性与女性的较小与较大AoR的预后意义不同。

较高的中心脉压与较高的颈股脉搏波速度(CFPWV)与血管疾病(CVD)风险增加有关。较小的主动脉根部直径(AoR)与较高的中心脉压有关。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员假设较小的AoR联合较高的CFPWV与CVD风险增加相关(相对于较大的AoR和较低的CFPWV)。

研究人员在基于社区的弗雷明汉研究(N=1970,平均年龄为60岁,57%为女性)中检验了这一假设。研究人员将参与者分为较小和较大的AoR组,并根据参与者的AoR变化轨迹和CFPWV(按性别中位数进行分类)对参与者进行了交叉分类。

研究人员使用Cox回归将交叉分类组与随访(中位17年)期间的CVD发生率相关联:较低的CFPWV,较大的AoR(对照组;6.4/1000人每年);较低的CFPWV,较小的AoR(6.9/1000人每年);较高的CFPWV,较大的AoR(23.1/1000人每年);和较高的CFPWV,较小的AoR(21.9/1000人每年)。在性别汇总分析中,无论AoR大小如何,具有较高CFPWV个体经多变量调整的CVD风险增加1.8倍(P<0.01)。研究人员观察到了性别效应的改变(性别×AoR-CFPWV组交互作用的P=0.04)。在男性中,具有较小AoR和较高CFPWV个体CVD风险增加2.5至2.8倍(P<0.001)。在女性中,具有较大AoR和较高CFPWV个体CVD风险增加了70%至80%,但无统计学意义。

该研究的结果表明,男性与女性的较小与较大AoR的预后意义不同。需要额外的研究来证实这一结果。

原始出处:

Ramachandran S. Vasan.et al.Aortic Root Diameter and Arterial Stiffness: Conjoint Relations to the Incidence of Cardiovascular Disease in the Framingham Heart Study.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17702

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    2021-10-12 查查佳佳

    气Fox垃圾人呢虚空间了没啊啊啊

    0

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