Ann Neurol:脑电图异常在COVID-19患者中很常见,并与预后相关

2021-03-21 MedSci原创 MedSci原创

这项多中心回顾性队列研究表明,癫痫发作和其他癫痫样异常在COVID-19患者中很常见,并与不良临床结局相关。

近日,神经病学领域权威取杂志Annals of Neurology上发表了一篇研究文章,这项研究旨在明确接受连续脑电图监测(cEEG)的COVID-19患者发生癫痫发作和其他脑电图模式的患病率和危险因素,并评估脑电图结果是否与预后相关。

研究人员在9个参与中心确认了197例COVID-19患者,他们接受了cEEG检查。研究人员回顾了参与者病历和脑电图报告,以确定癫痫发作和其他癫痫样模式的发生率和临床危险因素。多变量Cox比例风险分析评估脑电图模式与临床结局之间的关系。

19例(9.6%)患者出现癫痫发作,其中11例(5.6%)为无惊厥癫痫持续状态(NCSE)。96例(48.7%)出现癫痫样异常(发作期或发作间期)。住院期间之前的临床发作与脑电图发作(36.4% vs 8.1%,比值比(OR)为6.51, p=0.01)和NCSE (27.3% vs 4.3%,OR为8.34, p=0.01)相关。

在神经影像学上已经存在的颅内病变与NCSE相关(14.3% vs 3.7%;比值比为4.33,p=0.02)。在多因素结果分析中,癫痫发作是住院死亡率的独立预测因素(风险比(HR)为4.07[1.44‐11.51],p<0.01)。在竞争风险分析中,伴有NCSE的患者住院时间延长(伴有NCSE和不伴有NCSE的患者30天出院比例分别为0.21[0.03‐0.33]和0.43[0.36‐0.49])

这项多中心回顾性队列研究表明,癫痫发作和其他癫痫样异常在COVID-19患者中很常见,并与不良临床结局相关

原始出处:

Lu Lin,et al.EEG Abnormalities are Common in COVID‐19 and are Associated with Outcomes.Annals of Neurology.2021.https://doi.org/10.1002/ana.26060

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    2021-07-20 yinhl1978
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    2021-03-24 zhangxiang

    学习了,很好

    0

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    2021-03-21 WL

    漂亮

    0

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